Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Coffee, Caffeine, and Health In many countries, a large majority of adults consume caffeine
daily. This review summarizes the evidence about the varied physiological effects of caffeine …

Background Coffee is one of the most commonly consumed beverages in the world, but the
acute health effects of coffee consumption remain uncertain. Methods We conducted a …

Background: Previous observational studies have suggested an association between coffee
intake and reduced risk for death, but these studies did not distinguish between coffee …

Cardiovascular diseases (CVDs) are the world's leading killers, accounting for 30% deaths.
According to the WHO report, CVDs kill 17.9 million people per year, and there will be 22.2 …

The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

The purine alkaloid caffeine is the most widely consumed psychostimulant drug in the world
and has multiple beneficial pharmacological activities, for example, in neurodegenerative …

Background: Coffee consumption has been associated with reduced risk for death in
prospective cohort studies; however, data in nonwhites are sparse. Objective: To examine …

Abstract Context Type 2 diabetes (T2D) is a major health problem worldwide that is
associated with increased morbidity and mortality. There is increased interest in the value of …

This report evaluates the scientific literature on caffeine with respect to potential
cardiovascular outcomes, specifically relative risks of total cardiovascular disease (CVD) …