The genetics and pathology of mitochondrial disease

CL Alston, MC Rocha, NZ Lax… - The Journal of …, 2017 - Wiley Online Library
Mitochondria are double‐membrane‐bound organelles that are present in all nucleated
eukaryotic cells and are responsible for the production of cellular energy in the form of ATP …

The role of microbial motility and chemotaxis in symbiosis

JB Raina, V Fernandez, B Lambert, R Stocker… - Nature Reviews …, 2019 - nature.com
Many symbiotic relationships rely on the acquisition of microbial partners from the
environment. However, the mechanisms by which microbial symbionts find and colonize …

Updating the 97% identity threshold for 16S ribosomal RNA OTUs

RC Edgar - Bioinformatics, 2018 - academic.oup.com
Abstract Motivation The 16S ribosomal RNA (rRNA) gene is widely used to survey microbial
communities. Sequences are often clustered into Operational Taxonomic Units (OTUs) as …

Single-cell genome sequencing at ultra-high-throughput with microfluidic droplet barcoding

F Lan, B Demaree, N Ahmed, AR Abate - Nature biotechnology, 2017 - nature.com
The application of single-cell genome sequencing to large cell populations has been
hindered by technical challenges in isolating single cells during genome preparation. Here …

Stone Age Yersinia pestis genomes shed light on the early evolution, diversity, and ecology of plague

A Andrades Valtueña, GU Neumann… - Proceedings of the …, 2022 - pnas.org
The bacterial pathogen Yersinia pestis gave rise to devastating outbreaks throughout
human history, and ancient DNA evidence has shown it afflicted human populations as far …

Selfish, promiscuous and sometimes useful: how mobile genetic elements drive horizontal gene transfer in microbial populations

M Haudiquet, JM de Sousa… - … Transactions of the …, 2022 - royalsocietypublishing.org
Horizontal gene transfer (HGT) drives microbial adaptation but is often under the control of
mobile genetic elements (MGEs) whose interests are not necessarily aligned with those of …

Dynamic biofilm architecture confers individual and collective mechanisms of viral protection

L Vidakovic, PK Singh, R Hartmann, CD Nadell… - Nature …, 2018 - nature.com
In nature, bacteria primarily live in surface-attached, multicellular communities, termed
biofilms,,,,–. In medical settings, biofilms cause devastating damage during chronic and …

Obligate biotrophy features unraveled by the genomic analysis of rust fungi

S Duplessis, CA Cuomo, YC Lin, A Aerts… - Proceedings of the …, 2011 - pnas.org
Rust fungi are some of the most devastating pathogens of crop plants. They are obligate
biotrophs, which extract nutrients only from living plant tissues and cannot grow apart from …

Biodiversity of vibrios

FL Thompson, T Iida, J Swings - Microbiology and molecular …, 2004 - journals.asm.org
Vibrios are ubiquitous and abundant in the aquatic environment. A high abundance of
vibrios is also detected in tissues and/or organs of various marine algae and animals, eg …

Salmonella pathogenicity and host adaptation in chicken-associated serovars

SL Foley, TJ Johnson, SC Ricke, R Nayak… - Microbiology and …, 2013 - journals.asm.org
Enteric pathogens such as Salmonella enterica cause significant morbidity and mortality. S.
enterica serovars are a diverse group of pathogens that have evolved to survive in a wide …