Identifying causal factors for Mendelian and common diseases is an ongoing challenge in
medical genetics. Population bottleneck events, such as those that occurred in the history of …

Here, in a multi-ancestry genome-wide association study meta-analysis of kidney cancer
(29,020 cases and 835,670 controls), we identified 63 susceptibility regions (50 novel) …

Objective Previous observational studies demonstrated that a subset of patients with
systemic lupus erythematosus (SLE) have markedly short telomere length in leukocytes …

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting
0.5–2% of pregnancies. The majority of cases present in the third trimester with pruritus …

Existing research indicates that different types of meat have varying effects on health and
aging, but the specific causal relationships remain unclear. This study aimed to explore the …

Fuchs endothelial corneal dystrophy (FECD) is a leading indication for corneal
transplantation, but its molecular etiology remains poorly understood. We performed …

The aim of this study was to assess the causal relationships between mineral metabolism
disorders, representative of trace elements, and key aging biomarkers: telomere length (TL) …

Background Metabolic abnormalities are closely tied to the development of ovarian cancer
(OC), yet the relationship between anthropometric indicators as risk indicators for metabolic …

Background Expression quantitative trait loci (eQTL) studies show how genetic variants
affect downstream gene expression. Single-cell data allows reconstruction of personalized …

Background Some cancer patients derive limited benefit from anti-angiogenic therapy or
discontinuation due to adverse reactions. Vascular endothelial growth factor receptor 2 …