Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …

Cerebral cavernous malformations are acquired vascular anomalies that constitute a
common cause of central nervous system hemorrhage and stroke. The past 2 decades have …

CellProfiler has enabled the scientific research community to create flexible, modular image
analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new …

In morphological profiling, quantitative data are extracted from microscopy images of cells to
identify biologically relevant similarities and differences among samples based on these …

Deficiency in vitamin D (VitD), a lipid-soluble vitamin and steroid hormone, affects
approximately 24% to 40% of the population of the Western world. In addition to its well …

The endothelium is capable of remarkable plasticity. In the embryo, primitive endothelial
cells differentiate to acquire arterial, venous or lymphatic fates. Certain endothelial cells also …

Reactive oxygen species (ROS) mediate multiple physiological functions; however, the over-
accumulation of ROS causes premature aging and/or death and is associated with various …

Cerebral cavernous malformations (CCMs) are common inherited and sporadic vascular
malformations that cause strokes and seizures in younger individuals. CCMs arise from …

Patient-derived organoids resemble the biology of tissues and tumors, enabling ex vivo
modeling of human diseases. They have heterogeneous morphologies with unclear …

In recent years, the use of nanomaterials as biomimetic enzymes has attracted great interest.
In this work, we show the potential of biocompatible platinum nanoparticles (Pt NPs) as …