Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …

Nutrient composition and caloric intake have traditionally been used to devise optimized
diets for various phases of life. Adjustment of meal size and frequency have emerged as …

Intermittent and periodic fasting (IF and PF, respectively) are emerging as safe strategies to
affect longevity and healthspan by acting on cellular aging and disease risk factors, while …

BACKGROUND Reduced caloric intake without malnutrition is the oldest known life span–
extending intervention. Laboratory studies throughout the 20th century established and …

The importance of dietary composition and feeding patterns in aging remains largely
unexplored, but was implicated recently in two prominent nonhuman primate studies. Here …

Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

Abstract Purpose of Review This article reviews the current literature on dietary
interventions, including time-restricted eating (TRE), intermittent fasting (IF), and fasting …

Overnutrition is a risk factor for various human diseases, including neurodegenerative
diseases, metabolic disorders, and cancers. Therefore, targeting overnutrition represents a …

The number of people aged over 65 is expected to double in the next 30 years. For many,
living longer will mean spending more years with the burdens of chronic diseases such as …

Aging is a complex process that differentially impacts multiple cognitive, sensory, neuronal
and molecular processes. Technological innovations now allow for parallel investigation of …