The use of stem cells to model the early human embryo promises to transform our
understanding of developmental biology and human reproduction. In this review, we present …

Epigenetic reprogramming resets parental epigenetic memories and differentiates
primordial germ cells (PGCs) into mitotic pro-spermatogonia or oogonia. This process …

Our understanding of pluripotency remains limited: iPSC generation has only been
established for a few model species, pluripotent stem cell lines exhibit inconsistent …

Germline commitment following primordial germ cell (PGC) specification during early human
development establishes an epigenetic programme and competence for gametogenesis …

Human oogenesis is a highly complex and not yet fully understood process due to ethical
and technological barriers that limit studies in the field. In this context, replicating female …

Primordial germ cells (PGCs) are the precursors of gametes and the sole mechanism by
which animals transmit genetic information across generations. In the mouse embryo, the …

The germline provides the genetic and non-genetic information that passes from one
generation to the next. Given this important role in species propagation, egg and sperm …

Primordial germ cells (PGCs) are the precursors of sperm and eggs. They undergo genome-
wide epigenetic reprogramming to erase epigenetic memory and reset the genomic …

The generation of germline cells from human induced pluripotent stem cells (hiPSCs)
represents a milestone toward in vitro gametogenesis. Methods to recapitulate germline …

Male germ cells undergo a complex sequence of developmental events throughout fetal and
postnatal life that culminate in the formation of haploid gametes: the spermatozoa. Errors in …