[HTML][HTML] Immunologic insights in recurrent spontaneous abortion: Molecular mechanisms and therapeutic interventions

D Guan, W Sun, M Gao, Z Chen, X Ma - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Recurrent spontaneous abortion refers to the occurrence of two or more spontaneous
abortions before or during the early stages of pregnancy. The immune system plays a crucial …

Role of NLRP3 inflammasome in hepatocellular carcinoma: A double-edged sword

YL Tang, Y Tao, L Zhu, JL Shen, H Cheng - International …, 2023 - Elsevier
In recent years, the study of NOD-like receptor thermal protein domain associated protein 3
(NLRP3) inflammasome has become a hot topic, especially its role in various tumors. The …

Inhibition of HMGB1 ameliorates the maternal-fetal interface destruction in unexplained recurrent spontaneous abortion by suppressing pyroptosis activation

D Zhu, H Zou, J Liu, J Wang, C Ma, J Yin… - Frontiers in …, 2021 - frontiersin.org
Recurrent spontaneous abortion (RSA) is a common complication of pregnancy that affects
the physical and mental health of pregnant women, and approximately 50% of the …

A novel defined cuproptosis-related gene signature for predicting the prognosis of lung adenocarcinoma

H Zhang, Y Shi, Q Yi, C Wang, Q **a, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Lung adenocarcinoma (LUAD) has become the most prevalent histologic subset of primary
lung cancer, and effective innovative prognostic models are needed to enhance the …

Antileukemic effect of venetoclax and hypomethylating agents via caspase-3/GSDME-mediated pyroptosis

F Ye, W Zhang, C Fan, J Dong, M Peng… - Journal of Translational …, 2023 - Springer
Background The identifying of B-cell lymphoma 2 (Bcl-2) as a therapeutic target has led to a
paradigm shift in acute myeloid leukemia (AML) treatment. Pyroptosis is a novel antitumor …

Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines

Y Zhou, Y Kong, M Jiang, L Kuang, J Wan… - Cancer Biology & …, 2022 - Taylor & Francis
Curcumin, the primary bioactive component isolated from turmeric, has been found to
possess a variety of biological functions, including anti-leukemia activity. However, the effect …

Progress in the study of molecular mechanisms of cell pyroptosis in tumor therapy

D Wang, X Wan - International Immunopharmacology, 2023 - Elsevier
Pyroptosis, also known as cellular inflammatory necrosis, is a programmed cell death
mediated by the Gasdermin family of proteins. The mechanisms by which pyroptosis occurs …

Pyroptosis and the fight against lung cancer

J Wang, H Su, M Wang, R Ward, S An… - Medicinal Research …, 2025 - Wiley Online Library
Pyroptosis, a newly characterized type of inflammatory programmed cell death (PCD), is
usually triggered by multiple inflammasomes which can recognize different danger or …

Gasdermins: a dual role in pyroptosis and tumor immunity

J Yang, J Jiang - Frontiers in immunology, 2024 - frontiersin.org
The gasdermin (GSDM) protein family plays a pivotal role in pyroptosis, a process critical to
the body's immune response, particularly in combatting bacterial infections, impeding tumor …

Intracellular metal ion-based chemistry for programmed cell death

Y You, Z Guo, T Wolter, Q Hu - Chemical Society Reviews, 2025 - pubs.rsc.org
Intracellular metal ions play essential roles in multiple physiological processes, including
catalytic action, diverse cellular processes, intracellular signaling, and electron transfer. It is …