abstract Introduction: The use of computational tools in the early stages of drug development
has increased in recent decades. Machine learning (ML) approaches have been of special …

Computational prediction of intrinsic disorder in protein sequences dates back to late 1970
and has flourished in the last two decades. We provide a brief historical overview, and we …

The PSIPRED Workbench is a web server offering a range of predictive methods to the
bioscience community for 20 years. Here, we present the work we have completed to update …

The αβ T cell receptor (TCR), in association with the CD3γε–CD3δε–CD3ζζ signalling
hexamer, is the primary determinant of T cell development and activation, and of immune …

Gene regulation involves activation of RNA polymerase II (Pol II) that is paused and bound
by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation …

The COVID‐2019 pandemic is the most severe acute public health threat of the twenty‐first
century. To properly address this crisis with both robust testing and novel treatments, we …

Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport
between the cytoplasm and nucleoplasm. However, their large size and dynamic nature …

Metazoan gene regulation often involves the pausing of RNA polymerase II (Pol II) in the
promoter-proximal region. Paused Pol II is stabilized by the protein complexes DRB …

The human ether-à-go-go-related potassium channel (hERG, Kv11. 1) is a voltage-
dependent channel known for its role in repolarizing the cardiac action potential. hERG …

Mitochondrial electron transport chain complexes are organized into supercomplexes
responsible for carrying out cellular respiration. Here we present three architectures of …