Glioblastoma, a rare, and highly lethal form of brain cancer, poses significant challenges in
terms of therapeutic resistance, and poor survival rates for both adult and paediatric patients …

Abstract Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is
predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial …

Cancer cells are commonly subjected to endoplasmic reticulum (ER) stress. To gain survival
advantage, cancer cells exploit the adaptive aspects of the unfolded protein response such …

Acute myeloid leukemia (AML) poses a singular challenge for chimeric antigen receptor
(CAR) therapy owing to its phenotypic heterogeneity and similarity to normal hematopoietic …

Immunotherapy has rapidly evolved in the past decades in the battle against cancer.
Chimeric antigen receptor (CAR)-engineered T cells have demonstrated significant success …

Chimeric antigen receptor (CAR)-T cells have emerged as a promising treatment modality
for various hematologic and solid malignancies over the past decade. Animal models …

Chimeric antigen receptor (CAR)-mediated targeting of T lineage antigens for the therapy of
blood malignancies is frequently complicated by self-targeting of CAR T cells or their …

The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER)
causes ER stress and activates the unfolded protein response (UPR). As an adaptive …

The most common kind of acute leukemia in adults is acute myeloid leukemia (AML), which
is often treated with induction chemotherapy regimens followed by consolidation or …

GRP78 is a protein that acts as a chaperone within the endoplasmic reticulum (ER) and has
multiple functions. It is induced by stress and abets cells from survival. Despite, multiple …