Role of short-chain fatty acids in colonic inflammation, carcinogenesis, and mucosal protection and healing

CM van der Beek, CHC Dejong, FJ Troost… - Nutrition …, 2017 - academic.oup.com
Short-chain fatty acids (SCFAs), mainly acetate, propionate, and butyrate, produced by
microbial fermentation of undigested food substances are believed to play a beneficial role …

Microbiota-derived butyrate regulates intestinal inflammation: Focus on inflammatory bowel disease

MR Couto, P Gonçalves, F Magro, F Martel - Pharmacological Research, 2020 - Elsevier
Inflammatory bowel disease (IBD) refers to a group of heterogeneous disorders associated
with chronic inflammation of the gut, having a high rate of incidence in the world. In the …

Microbial shifts and signatures of long-term remission in ulcerative colitis after faecal microbiota transplantation

S Fuentes, NG Rossen, MJ van der Spek… - The ISME …, 2017 - academic.oup.com
Faecal microbiota transplantation (FMT) may contribute towards disease remission in
ulcerative colitis (UC), but it is unknown which factors determine long-term effect of …

Butyrate does not protect against inflammation-induced loss of epithelial barrier function and cytokine production in primary cell monolayers from patients with …

M Vancamelbeke, T Laeremans… - Journal of Crohn's …, 2019 - academic.oup.com
Abstract Background and Aims In vitro studies using immortalised cancer cell lines showed
that butyrate has an overall positive effect on epithelial barrier integrity, but the physiological …

Microbiome–epigenome interactions and the environmental origins of inflammatory bowel diseases

TY Fofanova, JF Petrosino… - Journal of pediatric …, 2016 - journals.lww.com
The incidence of pediatric inflammatory bowel disease (IBD), which includes Crohn disease
and ulcerative colitis, has risen alarmingly in the Western and develo** world in recent …

Decreased expression of G-protein-coupled receptors GPR43 and GPR109a in psoriatic skin can be restored by topical application of sodium butyrate

A Krejner, A Bruhs, U Mrowietz, U Wehkamp… - Archives of …, 2018 - Springer
The G-protein-coupled receptors GPR43 and GPR109a are known to play an important role
in mediating anti-inflammatory and anti-cancer functions in the gut. Short-chain fatty acids …

[HTML][HTML] Microbiome, gut dysbiosis and inflammatory bowel disease: That moment when the function is more important than taxonomy

SI Sitkin, TY Vakhitov, EV Demyanova - Almanac of clinical medicine, 2018 - almclinmed.ru
The altered gut microbiome (dysbiosis) is involved in the pathogenesis of most non-
infectious gastrointestinal diseases, such as inflammatory bowel disease (IBD), irritable …

Differential contributions of the gut microbiota and metabolome to pathomechanisms in ulcerative colitis: an in vitro analysis

J Poppe, L Boesmans, S Vieira-Silva, L Deroover… - Gut …, 2024 - Taylor & Francis
The gut microbiota has been implicated in onset and progression of ulcerative colitis (UC).
Here, we assess potential causal involvement of the microbiota and-associated fecal water …

Микробиом, дисбиоз толстой кишки и воспалительные заболевания кишечника: когда функция важнее таксономии

СИ Ситкин, ТЯ Вахитов… - Альманах клинической …, 2018 - cyberleninka.ru
Измененный микробиом кишечника (дисбиоз) вовлечен в патогенез большинства
неинфекционных заболеваний органов пищеварения–воспалительные заболевания …

Characterization of the pro‐inflammatory cytokine IL‐1β on butyrate oxidation in colorectal cancer cells

M Johnstone, N Bennett, C Standifer… - Journal of Cellular …, 2017 - Wiley Online Library
Cancer, in part, is driven, by alterations in cellular metabolism that promote cell survival and
cell proliferation. Identifying factors that influence this shift in cellular metabolism in cancer …