Hypertriglyceridemia (HTG) is a metabolic disorder, defined when serum or plasma
triglyceride concentration (seTG) is> 1.7 mM. HTG can be categorized as mild to very severe …

Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known
about its pathogenesis, and there is no specific or effective treatment. Its development …

Background & Aims Little is known about the signaling pathways that initiate and promote
acute pancreatitis (AP). The pathogenesis of AP has been associated with abnormal …

Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

Pancreatic acinar cells possess very high protein synthetic rates as they need to produce
and secrete large amounts of digestive enzymes. Acinar cell damage and dysfunction cause …

Background & Aims Acinar to ductal metaplasia (ADM) occurs in the pancreas in response
to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies …

While most cases of pancreatitis in dogs are thought to be idiopathic, potential risk factors
are identified. In this article we provide a state‐of‐the‐art overview of suspected risk factors …

The metabolic stress hormone FGF21 is highly expressed in exocrine pancreas, where its
levels are increased by refeeding and chemically induced pancreatitis. However, its function …

Knowledge of the molecular mechanisms of acute pancreatitis is largely based on studies
using rodents. To assess similar mechanisms in humans, we performed ex vivo pancreatitis …

The pancreas is a glandular organ with endocrine and exocrine functions necessary for the
maintenance of blood glucose homeostasis and secretion of digestive enzymes. Pancreatitis …