Recent advances in microwave-assisted multicomponent synthesis of spiro heterocycles
Spiro heterocycle frameworks are a class of organic compounds that possesses unique
structural features making them highly sought-after targets in drug discovery due to their …
structural features making them highly sought-after targets in drug discovery due to their …
Single Step Upgradation of Isatin to Bioactive Fused Heterocycles via Ring Expansion Reactions
Isatin, also known as indoline‐2, 3‐dione, is a fused, N‐heterocyclic aromatic compound first
isolated and purified in 1841. Since then, isatin and its derivatives emerged as a hot …
isolated and purified in 1841. Since then, isatin and its derivatives emerged as a hot …
Novel functionalized spiro [Indoline-3, 5′-pyrroline]-2, 2′ dione derivatives: synthesis, characterization, drug-likeness, ADME, and anticancer potential
A highly stereo-selective, one-pot, multicomponent method was chosen to synthesize the
novel functionalized 1, 3-cycloaddition spirooxindoles (SOXs)(4a–4h). Synthesized SOXs …
novel functionalized 1, 3-cycloaddition spirooxindoles (SOXs)(4a–4h). Synthesized SOXs …
Organocatalytic Asymmetric [4+ 2]-Cycloadditions of 2-Aminophenyl Enones with Isatin-Derived Ketimines: Diastereo-and Enantioselective Synthesis of Spirooxindole …
JW Han, Y Kim, SG Kim - Organic Letters, 2023 - ACS Publications
A novel method for the enantioselective synthesis of spiro N, N-heterocyclic oxindoles has
been developed, employing asymmetric [4+ 2]-cycloadditions of 2-aminophenyl enones with …
been developed, employing asymmetric [4+ 2]-cycloadditions of 2-aminophenyl enones with …
Lewis base-catalyzed synthesis of highly functionalized spirooxindole-pyranopyrazoles and their in vitro anticancer studies
Herein, the one-step, multi-component reaction (MCR) of a series of spirooxindole-
pyranopyrazole derivatives (5a-g), via a Knoevenagel condensation and Michael addition …
pyranopyrazole derivatives (5a-g), via a Knoevenagel condensation and Michael addition …
Synthesis of Functionalized 2′, 5‐Oxo‐spiro [furan‐2, 3′‐indoline]‐3‐carboxylate Derivatives as Antiproliferative Agents: ADMET Studies, and Molecular Docking …
Herein, we present a one‐pot, three‐component synthesis of spirooxindole‐oxofuran
carboxylate derivatives (4 a–d) through the Huisgen reaction. The newly synthesized …
carboxylate derivatives (4 a–d) through the Huisgen reaction. The newly synthesized …
Synthesis, characterization, pharmaceutical evaluation, molecular docking and DFT calculations of a novel drug (E)-5-bromo-3-(phenylimino) indolin-2-one
Herein, one-pot synthesis of (E)-5-bromo-3-(phenylimino) indolin-2-one (5BPI molecule),
density function theory for validation of the synthesized molecule, and biological activities …
density function theory for validation of the synthesized molecule, and biological activities …
One-Pot, Five-Component Condensation Reaction of Isatin, Secondary Amines, Malononitrile, Alcohols, and Molecular Oxygen to Access 3-Functionalized 2 …
An efficient five-component condensation reaction of isatin, malononitrile, secondary
amines, alcohols, and molecular oxygen was discovered. The reaction was performed in a …
amines, alcohols, and molecular oxygen was discovered. The reaction was performed in a …
Medicinal significance of sp2/sp3 hybridized at C-3-substituted indole-containing lead molecules and FDA-approved drugs
Herein, the privilege in favor of biological importance of indole-containing scaffolds related
to the semi-synthetic and extracted from natural sources is summarized. Such compounds …
to the semi-synthetic and extracted from natural sources is summarized. Such compounds …
A Perspective of the Amide Group Containing FDA Approved Anticancer Drugs from 2021–2022 (A Review)
M Asif, R Srivastava, A Fatima, M Shakeel… - Russian Journal of …, 2023 - Springer
In this review, we describe a collection and assessment of 16 anticancer drugs approved by
the US FDA between 2021 to June 2022, which include small and big amide group …
the US FDA between 2021 to June 2022, which include small and big amide group …