The Good and the Bad of SHROOM3 in Kidney Development and Disease: A Narrative Review
A Paul, A Lawlor, K Cunanan… - … Journal of Kidney …, 2023 - journals.sagepub.com
Purpose of review: Multiple large-scale genome-wide association meta-analyses studies
have reliably identified an association between genetic variants within the SHROOM3 gene …
have reliably identified an association between genetic variants within the SHROOM3 gene …
[HTML][HTML] Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-
decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci …
decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci …
Genome-wide association study of hospitalized patients and acute kidney injury
ED Siew, JN Hellwege, AM Hung, BC Birkelo… - Kidney international, 2024 - Elsevier
Acute kidney injury (AKI) is a common and devastating complication of hospitalization. Here,
we identified genetic loci associated with AKI in patients hospitalized between 2002-2019 in …
we identified genetic loci associated with AKI in patients hospitalized between 2002-2019 in …
The Critical Role of the Shroom Family Proteins in Morphogenesis, Organogenesis and Disease
W Liu, L **u, M Zhou, T Li, N Jiang, Y Wan, C Qiu, J Li… - Phenomics, 2024 - Springer
Abstract The Shroom (Shrm) family of actin-binding proteins has a unique and highly
conserved Apx/Shrm Domain 2 (ASD2) motif. Shroom protein directs the subcellular …
conserved Apx/Shrm Domain 2 (ASD2) motif. Shroom protein directs the subcellular …
Minimal Kidney Disease Phenotype in Shroom3 Heterozygous Null Mice
A Lawlor, K Cunanan, J Cunanan… - … Journal of Kidney …, 2023 - journals.sagepub.com
Background: Shroom family member 3 (SHROOM3) encodes an actin-associated protein
that regulates epithelial morphology during development. Several genome-wide association …
that regulates epithelial morphology during development. Several genome-wide association …
Shroom3, a gene associated with CKD, modulates epithelial recovery after AKI
Background Ischemia-induced AKI resulting in tubular damage can often progress to CKD
and is a common cause of nephrology consultation. After renal tubular epithelial damage …
and is a common cause of nephrology consultation. After renal tubular epithelial damage …
Emerging insights into chronic renal disease pathogenesis in hypertension from human and animal genomic studies
The pathogenic links between elevated blood pressure and chronic kidney disease remain
obscure. This article examines progress in population genetics and in animal models of …
obscure. This article examines progress in population genetics and in animal models of …
Integrating bioinformatic analysis and detailed experiments reveal an EMT‐related biomarker for clear cell renal cell carcinoma
Y Ge, S Ma, J Zhang, Z **ong, B Li, S Ma… - Cancer …, 2023 - Wiley Online Library
Background Epithelial–mesenchymal transition (EMT) is associated with early recurrence
and a poor prognosis in clear cell renal cell carcinoma (ccRCC). Studies have shown that …
and a poor prognosis in clear cell renal cell carcinoma (ccRCC). Studies have shown that …
Genome-wide association studies reconstructing chronic kidney disease
Chronic kidney disease (CKD) is a major health problem with an increasing epidemiological
burden, and is the 16th leading cause of years of life lost worldwide. It is estimated that more …
burden, and is the 16th leading cause of years of life lost worldwide. It is estimated that more …
Phenotypic spectrum of FAM47E-SHROOM3 haplotype composition in a general population sample
Genome-wide association studies identified a locus on chromosome 4q21. 1, spanning the
FAM47E, STBD1, CCDC158, and SHROOM3 genes, as associated with kidney function …
FAM47E, STBD1, CCDC158, and SHROOM3 genes, as associated with kidney function …