Discovery of point mutations in the genes encoding isocitrate dehydrogenases (IDH) in
gliomas about a decade ago has challenged our view of the role of metabolism in tumor …

Isocitrate dehydrogenase (IDH) is the key metabolic enzyme that catalyzes the conversion of
isocitrate to α-ketoglutarate (α-KG). Two main types of IDH1 and IDH2 are present in …

Gliomas are highly lethal tumours characterised by heterogeneous molecular features,
producing various metabolic phenotypes leading to therapeutic resistance. Lipid metabolism …

Gliomas are highly aggressive cancer types that are in urgent need of novel drugs and
targeted therapies. Treatment protocols have not improved in over a decade, and glioma …

Members of the Omp85 superfamily of outer membrane proteins (OMPs) found in Gram-
negative bacteria, mitochondria and chloroplasts are characterized by a distinctive 16 …

In this review, we discuss the use of the alkylating agent temozolomide (TMZ) in the
treatment of IDH-mutant gliomas. We describe the challenges associated with TMZ in clinical …

Background Formalin-fixed, paraffin-embedded (FFPE) tissue slides are routinely used in
cancer diagnosis, clinical decision-making, and stored in biobanks, but their utilization in …

Acute myeloid leukemia (AML) is an aggressive, heterogenous malignancy characterized by
clonal expansion of bone marrow-derived myeloid progenitor cells. While our current …

The development of a fast and accurate intraoperative method that enables the
differentiation and stratification of cancerous lesions is still a challenging problem in …

The mechanism by which SARS-CoV-2 causes neurological post-acute sequelae of SARS-
CoV-2 (neuro-PASC) remains unclear. Herein, we conducted proteomic and metabolomic …