Innate immunity in tuberculosis: host defense vs pathogen evasion

CH Liu, H Liu, B Ge - Cellular & molecular immunology, 2017 - nature.com
The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …

[HTML][HTML] PI3K inhibitors in inflammation, autoimmunity and cancer

AK Stark, S Sriskantharajah, EM Hessel… - Current opinion in …, 2015 - Elsevier
Highlights•Preclinical studies support us of PI3K inhibitors in autoimmunity and
inflammation.•First in class PI3K inhibitor has been approved for treatment of B cell …

[BOEK][B] Molecular medical microbiology

YW Tang, M Hindiyeh, D Liu, A Sails, P Spearman… - 2023 - books.google.com
Molecular Medical Microbiology, Third Edition presents the latest release in what is
considered to be the first book to synthesize new developments in both molecular and …

Pro-and anti-inflammatory cytokines in tuberculosis: a two-edged sword in TB pathogenesis

MP Etna, E Giacomini, M Severa, EM Coccia - Seminars in immunology, 2014 - Elsevier
A major challenge in tuberculosis (TB) is to improve current vaccination and therapeutic
strategies and this requires a fine understanding of the mechanisms that mediate protection …

Immunoinformatics and structural aided approach to develop multi-epitope based subunit vaccine against Mycobacterium tuberculosis

G Sethi, RP Varghese, AK Lakra, SS Nayak… - Scientific Reports, 2024 - nature.com
Tuberculosis is a highly contagious disease caused by Mycobacterium tuberculosis (Mtb),
which is one of the prominent reasons for the death of millions worldwide. The bacterium …

Extracellular vesicles from infected cells: potential for direct pathogenesis

A Schwab, SS Meyering, B Lepene… - Frontiers in …, 2015 - frontiersin.org
Infections that result in natural or manmade spread of lethal biological agents are a concern
and require national and focused preparedness. In this manuscript, as part of an early …

Pathogenesis of SARS-CoV-2 and Mycobacterium tuberculosis Coinfection

T Shah, Z Shah, N Yasmeen, Z Baloch… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, is an infectious disease
that poses severe threats to global public health and significant economic losses. The …

Mycobacterium tuberculosis hijacks host macrophages-derived interleukin 16 to block phagolysosome maturation for enhancing intracellular growth

H Su, S Weng, L Luo, Q Sun, T Lin, H Ma… - Emerging Microbes & …, 2024 - Taylor & Francis
The discovery of promising cytokines and clarification of their immunological mechanisms in
controlling the intracellular fate of Mycobacterium tuberculosis (Mtb) are necessary to …

Concentration‐dependent, dual roles of IL‐10 in the osteogenesis of human BMSCs via P38/MAPK and NF‐κB signaling pathways

E Chen, G Liu, X Zhou, W Zhang, C Wang… - The FASEB …, 2018 - Wiley Online Library
Microenvironmental conditions can influence the differentiation and functional roles of
mesenchymal stem cells (MSCs). Recent studies have suggested that an inflammatory …

Toxin–antitoxin systems and regulatory mechanisms in Mycobacterium tuberculosis

RA Slayden, CC Dawson… - Pathogens and …, 2018 - academic.oup.com
There has been a significant reduction in annual tuberculosis incidence since the World
Health Organization declared tuberculosis a global health threat. However, treatment of M …