Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells.
Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is …

Aim Clinical resistance is a complex phenomenon in major human cancers involving
multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular …

Under conditions of hypoxia, most eukaryotic cells can shift their primary metabolic strategy
from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP …

Hypoxia induicible factor-1 alpha (HIF-1α) is a key transcription factor in cancer progression
and target therapy in cancer. HIF-1α acts differently depending on presence or absence of …

Erythropoietin (Epo) is the master regulator of erythropoiesis and oxygen homeostasis.
Despite its physiological importance, the molecular and genomic contexts of the cells …

The review presents a detailed discussion of the evolving field studying interactions
between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes …

Since the discovery of hypoxia-inducible factor (HIF), numerous studies on the hypoxia
signaling pathway have been performed. The role of HIF stabilization during hypoxia has …

The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …