The pinacol rearrangement1 is a well-known reaction. It refers to the acid-catalyzed
transformation of 1, 2-diols to ketones or aldehydes by 1, 2-migration of a CÀC or CÀH bond …

Quaternary carbon stereocenters are found in a broad range of organic compounds,
including important bioactive natural products and medicinal agents. Given their ubiquity …

The addition of electrophilic reagents to the carbon–carbon double bond is one of the most
fundamental reactions in organic chemistry. Halogen electrophiles constitute probably the …

Asymmetric catalysis for chiral compound synthesis is a rapidly growing field in modern
organic chemistry. Asymmetric catalytic processes have been indispensable for the …

A novel asymmetric halogenation/semipinacol rearrangement reaction catalyzed by
cinchona alkaloid derivatives was developed. Two types of β-haloketones (X= Br, Cl) were …

Suzuki coupling of 7 to 8 gave the biphenyl derivative 9. Reaction of 9 with ethyl vinyl
ether/bromine/base gave 10, which on treatment with CsF/DMF at 130° C resulted in the …

Over the past few decades, the semipinacol rearrangement has been widely applied in the
field of organic synthesis. However, its catalytic asymmetric version has not caught much …

Morphine, which is selected as an essential medicine by World Health Organization, is
widely applied in the treatment of the pain-related diseases. Due to its synthetically …

The Mannich reaction has been widely used to effectively construct C–N and C–C bonds in
organic synthesis. This review focuses on selected applications of the intramolecular …

Galantamine is a natural product that has attracted the interest of a number of researchers in
a collaborative effort aimed at designing novel biologically active compounds for the …