Chemical Biology of H2S Signaling through Persulfidation

MR Filipovic, J Zivanovic, B Alvarez… - Chemical …, 2018 - ACS Publications
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome

BD Paul, MD Lemle, AL Komaroff… - Proceedings of the …, 2021 - National Acad Sciences
Although most patients recover from acute COVID-19, some experience postacute sequelae
of severe acute respiratory syndrome coronavirus 2 infection (PASC). One subgroup of …

Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

JL Wallace, R Wang - Nature reviews Drug discovery, 2015 - nature.com
Hydrogen sulfide (H2S) has become recognized as an important signalling molecule
throughout the body, contributing to many physiological and pathological processes. In …

GPx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues

M Maiorino, M Conrad, F Ursini - Antioxidants & redox signaling, 2018 - liebertpub.com
Significance: Iron-dependent lipid peroxidation is a complex oxidative process where
phospholipid hydroperoxides (PLOOH) are produced in membranes and finally transformed …

Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation

D Giovinazzo, B Bursac, JI Sbodio… - Proceedings of the …, 2021 - National Acad Sciences
Alzheimer's disease (AD), the most common cause of dementia and neurodegeneration in
the elderly, is characterized by deterioration of memory and executive and motor functions …

Ferroptosis inhibition: mechanisms and opportunities

JPF Angeli, R Shah, DA Pratt, M Conrad - Trends in pharmacological …, 2017 - cell.com
The past decade has yielded tremendous insights into how cells die. This has come with our
understanding that several distinct forms of cell death are encompassed under the umbrella …

Selective persulfide detection reveals evolutionarily conserved antiaging effects of S-sulfhydration

J Zivanovic, E Kouroussis, JB Kohl, B Adhikari… - Cell metabolism, 2019 - cell.com
Life on Earth emerged in a hydrogen sulfide (H 2 S)-rich environment eons ago and with it
protein persulfidation mediated by H 2 S evolved as a signaling mechanism. Protein …

Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems

VS Lin, W Chen, M **an, CJ Chang - Chemical Society Reviews, 2015 - pubs.rsc.org
Hydrogen sulfide (H2S), a gaseous species produced by both bacteria and higher
eukaryotic organisms, including mammalian vertebrates, has attracted attention in recent …

Ferroptosis and its potential role in human diseases

C Han, Y Liu, R Dai, N Ismail, W Su, B Li - Frontiers in pharmacology, 2020 - frontiersin.org
Ferroptosis is a novel regulated cell death pattern discovered when studying the mechanism
of erastin-killing RAS mutant tumor cells in 2012. It is an iron-dependent programmed cell …