Chemical Biology of H2S Signaling through Persulfidation
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …
Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome
Although most patients recover from acute COVID-19, some experience postacute sequelae
of severe acute respiratory syndrome coronavirus 2 infection (PASC). One subgroup of …
of severe acute respiratory syndrome coronavirus 2 infection (PASC). One subgroup of …
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter
Hydrogen sulfide (H2S) has become recognized as an important signalling molecule
throughout the body, contributing to many physiological and pathological processes. In …
throughout the body, contributing to many physiological and pathological processes. In …
GPx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues
Significance: Iron-dependent lipid peroxidation is a complex oxidative process where
phospholipid hydroperoxides (PLOOH) are produced in membranes and finally transformed …
phospholipid hydroperoxides (PLOOH) are produced in membranes and finally transformed …
Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation
D Giovinazzo, B Bursac, JI Sbodio… - Proceedings of the …, 2021 - National Acad Sciences
Alzheimer's disease (AD), the most common cause of dementia and neurodegeneration in
the elderly, is characterized by deterioration of memory and executive and motor functions …
the elderly, is characterized by deterioration of memory and executive and motor functions …
Ferroptosis inhibition: mechanisms and opportunities
The past decade has yielded tremendous insights into how cells die. This has come with our
understanding that several distinct forms of cell death are encompassed under the umbrella …
understanding that several distinct forms of cell death are encompassed under the umbrella …
Selective persulfide detection reveals evolutionarily conserved antiaging effects of S-sulfhydration
Life on Earth emerged in a hydrogen sulfide (H 2 S)-rich environment eons ago and with it
protein persulfidation mediated by H 2 S evolved as a signaling mechanism. Protein …
protein persulfidation mediated by H 2 S evolved as a signaling mechanism. Protein …
Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems
Hydrogen sulfide (H2S), a gaseous species produced by both bacteria and higher
eukaryotic organisms, including mammalian vertebrates, has attracted attention in recent …
eukaryotic organisms, including mammalian vertebrates, has attracted attention in recent …
Ferroptosis and its potential role in human diseases
C Han, Y Liu, R Dai, N Ismail, W Su, B Li - Frontiers in pharmacology, 2020 - frontiersin.org
Ferroptosis is a novel regulated cell death pattern discovered when studying the mechanism
of erastin-killing RAS mutant tumor cells in 2012. It is an iron-dependent programmed cell …
of erastin-killing RAS mutant tumor cells in 2012. It is an iron-dependent programmed cell …