Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Neutrophils are abundant immune cells in the circulation and frequently infiltrate tumors in
substantial numbers. However, their precise functions in different cancer types remain …

Objective: This meta-analysis was designed to explore the association between the systemic
immune–inflammation index (SII) and the therapeutic effect of immune checkpoint inhibitors …

Firefighting is physically and physiologically exhausting besides encompassing exposure to
toxic fire emissions. Biomonitoring studies from the past five years have been significantly …

Background To build a predictive scoring model based on simple immune and inflammatory
parameters to predict postoperative survival in patients with breast cancer. Methods We …

Simple Summary Tumor angiogenesis is one of the most critical steps in the progression of
cancer. Owing to its fundamental role in tumor growth and metastasis, tumor angiogenesis is …

A cytokine storm is an abnormal discharge of soluble mediators following an inappropriate
inflammatory response that leads to immunopathological events. Cytokine storms can occur …

Immune checkpoint blockade (ICB) targeting programmed cell death protein 1 (PD-1) and
cytotoxic T lymphocyte protein 4 (CTLA-4) can induce remarkable, yet unpredictable …

Inflammation is a complex physiological process that plays a pivotal role in many if not all
pathological conditions, including infectious as well as inflammatory diseases, like …