Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

In the last few decades, there has been a growing interest in Bruton's tyrosine kinase (BTK)
and the compounds that target it. BTK is a downstream mediator of the B-cell receptor (BCR) …

Simple Summary Since its first description 35 years ago, the transcription factor NF-κB
(nuclear factor κ-light-chain-enhancer of activated B cells) has been shown to be a key …

Several countries around the world have faced an important obesity challenge for the past
four decades as the result of an obesogenic environment. This disease has a multifactorial …

Diabetic cardiomyopathy (DCM), a serious diabetic complication, is a kind of low-grade
inflammatory cardiovascular disorder. Due to the high risk of morbidity and mortality, DCM …

Cerebral ischemia is a pathological condition resulting from the cessation or reduction of
blood supply to the cerebral arteries. Neurological deficits that are clinically relevant can …

Diabetic kidney disease (DKD) is a prevalent and severe complications of diabetes and
serves as the primary cause of end-stage kidney disease (ESKD) globally. Increasing …

The clinical success of the two BTK inhibitors, ibrutinib and acalabrutinib, represents a major
breakthrough in the treatment of chronic lymphocytic leukemia (CLL) and has also …

Activity of the NLRP3 inflammasome, a critical mediator of inflammation, is controlled by
accessory proteins, posttranslational modifications, cellular localization, and …

Acute lung injury (ALI) is a disease characterized by pulmonary diffusion dysfunction and its
exacerbation stage is acute respiratory distress syndrome (ARDS), which may develop to …