Bone has a remarkable endogenous regenerative capacity that enables scarless healing
and restoration of its prior mechanical function, even under challenging conditions such as …

Hematologic parameters are important markers of disease in human and veterinary
medicine. Biomedical research has benefited from mouse models that recapitulate such …

Despite their cytotoxic capacity, neutrophils are often co-opted by cancers to promote
immunosuppression, tumor growth, and metastasis. Consequently, these cells have …

Immune system defects are at the center of aging and a range of diseases. Here, we show
that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell …

Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …

Bone marrow transplantation is the primary therapy for numerous hematopoietic disorders.
The efficiency of bone marrow transplantation depends on the function of long-term …

Lymphocytes and neutrophils are rapidly depleted by systemic infection. Progenitor cells of
the haematopoietic system, such as common myeloid progenitors and common lymphoid …

Epigenetic regulation of hematopoietic stem cells (HSCs) ensures lifelong production of
blood and bone marrow. Recently, we reported that loss of de novo DNA methyltransferase …

The traditional view of hematopoiesis has been that all the cells of the peripheral blood are
the progeny of a unitary homogeneous pool of hematopoietic stem cells (HSCs). Recent …

Hematopoietic stem cells (HSCs) are the progenitors of all blood and immune cells, yet their
role in immunity is not well understood. Most studies have focused on the ability of …