Human organs-on-chips for disease modelling, drug development and personalized medicine
DE Ingber - Nature Reviews Genetics, 2022 - nature.com
The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …
Organs-on-chips: into the next decade
LA Low, C Mummery, BR Berridge, CP Austin… - Nature Reviews Drug …, 2021 - nature.com
Abstract Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue
chips'(the terms are synonymous), have attracted substantial interest in recent years owing …
chips'(the terms are synonymous), have attracted substantial interest in recent years owing …
A role for microfluidic systems in precision medicine
Precision oncology continues to challenge the “one-size-fits-all” dogma. Under the precision
oncology banner, cancer patients are screened for molecular tumor alterations that predict …
oncology banner, cancer patients are screened for molecular tumor alterations that predict …
Three-dimensional in vitro culture models in oncology research
Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …
Modelling cancer in microfluidic human organs-on-chips
One of the problems that has slowed the development and approval of new anticancer
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …
Beyond polydimethylsiloxane: alternative materials for fabrication of organ-on-a-chip devices and microphysiological systems
Polydimethylsiloxane (PDMS) is the predominant material used for organ-on-a-chip devices
and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical …
and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical …
Integrating organoids and organ-on-a-chip devices
Organoids and organs-on-chips are two rapidly emerging 3D cell culture techniques that
aim to bridge the gap between in vitro 2D cultures and animal models to enable clinically …
aim to bridge the gap between in vitro 2D cultures and animal models to enable clinically …
Engineering vascularized organoid-on-a-chip models
Recreating human organ–level function in vitro is a rapidly evolving field that integrates
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …
3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip
Decades of efforts in engineering in vitro cancer models have advanced drug discovery and
the insight into cancer biology. However, the establishment of preclinical models that enable …
the insight into cancer biology. However, the establishment of preclinical models that enable …
The tumor-on-chip: Recent advances in the development of microfluidic systems to recapitulate the physiology of solid tumors
G Trujillo-de Santiago, BG Flores-Garza… - Materials, 2019 - mdpi.com
The ideal in vitro recreation of the micro-tumor niche—although much needed for a better
understanding of cancer etiology and development of better anticancer therapies—is highly …
understanding of cancer etiology and development of better anticancer therapies—is highly …