Telomeres are the heterochromatic repeat regions at the ends of eukaryotic chromosomes,
whose length is considered to be a determinant of biological ageing. Normal ageing itself is …

DNA damage is correlated with and may drive the ageing process. Neurons in the brain are
postmitotic and are excluded from many forms of DNA repair; therefore, neurons are …

An ageing world population has fuelled interest in regenerative remedies that may stem
declining organ function and maintain fitness. Unanswered is whether elimination of intrinsic …

Oxidative stress has been identified as an important contributor to neurodegeneration
associated with acute CNS injuries and diseases such as spinal cord injury (SCI), traumatic …

The telomerase reverse transcriptase protein TERT has recently been demonstrated to have
a variety of functions both in vitro and in vivo, which are distinct from its canonical role in …

Telomeres, ribonucleoprotein complexes that cap eukaryotic chromosomes, typically
shorten in leukocytes with aging. Aging is a primary risk factor for neurodegenerative …

The old age population is increasing worldwide as well as age related diseases, including
neurodegenerative disorders, such as Alzheimer's disease (AD), which negatively impacts …

Microglia activation and associated inflammation are implicated in the periventricular white
matter damage (PWMD) in septic postnatal rats. This study investigated whether melatonin …

Eight human and six chicken novel alternatively spliced (AS) variants of telomerase reverse
transcriptase (TERT) were identified, including a human variant (Δ4-13) containing an in …

Aging is a gradual process during which molecular and cellular processes deteriorate
progressively, often leading to such pathological conditions as vascular and metabolic …