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Complement activation, regulation, and molecular basis for complement‐related diseases
The complement system is an essential element of the innate immune response that
becomes activated upon recognition of molecular patterns associated with microorganisms …
becomes activated upon recognition of molecular patterns associated with microorganisms …
Complement regulators and inhibitory proteins
The complement system is important for cellular integrity and tissue homeostasis.
Complement activation mediates the removal of microorganisms and the clearance of …
Complement activation mediates the removal of microorganisms and the clearance of …
Complement and its receptors: new insights into human disease
VM Holers - Annual review of immunology, 2014 - annualreviews.org
Although new activation and regulatory mechanisms are still being identified, the basic
architecture of the complement system has been known for decades. Two major roles of …
architecture of the complement system has been known for decades. Two major roles of …
Membranoproliferative glomerulonephritis—a new look at an old entity
This review discusses the causes, pathogenesis, and clinical management of
membranoproliferative glomerulonephritis, which accounts for 7 to 10% of biopsy-confirmed …
membranoproliferative glomerulonephritis, which accounts for 7 to 10% of biopsy-confirmed …
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress
Oxidative stress and enhanced lipid peroxidation are linked to many chronic inflammatory
diseases, including age-related macular degeneration (AMD). AMD is the leading cause of …
diseases, including age-related macular degeneration (AMD). AMD is the leading cause of …
The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited
During the past ten years, dramatic advances have been made in unraveling the biological
bases of age-related macular degeneration (AMD), the most common cause of irreversible …
bases of age-related macular degeneration (AMD), the most common cause of irreversible …
[HTML][HTML] The multifaceted impact of complement on atherosclerosis
As one of the cornerstones of innate immunity, the complement system has long been
implicated in the pathogenesis of atherosclerosis. Growing evidence demonstrates the …
implicated in the pathogenesis of atherosclerosis. Growing evidence demonstrates the …
Age-related macular degeneration revisited–piecing the puzzle: the LXIX Edward Jackson memorial lecture
PURPOSE: To present the current understanding of age-related macular degeneration
(AMD) pathogenesis, based on clinical evidence, epidemiologic data, histopathologic …
(AMD) pathogenesis, based on clinical evidence, epidemiologic data, histopathologic …
Oxidative stress, innate immunity, and age-related macular degeneration
Age-related macular degeneration (AMD) is a leading cause of vision loss affecting tens of
millions of elderly worldwide. Early AMD is characterized by the appearance of soft drusen …
millions of elderly worldwide. Early AMD is characterized by the appearance of soft drusen …
The role of complement in tumor growth
Complement is a central part of the immune system that has developed as a first defense
against non-self cells. Neoplastic transformation is accompanied by an increased capacity of …
against non-self cells. Neoplastic transformation is accompanied by an increased capacity of …