Plants are rich sources of a diverse range of chemicals, many of which have significant
metabolic activity. One large group of secondary compounds are the phenolics, which act as …

Inflammatory disorders such as atherosclerosis, diabetes and rheumatoid arthritis are
regulated by cytokines and other inflammatory mediators. Current treatments for these …

Saffron petal (SP) is an agricultural byproduct in the process of the crude drug saffron,
accounting for 90% of the dry weight of saffron flowers. To promote the utilization of SP in the …

Context The reduction in M2 macrophage polarisation plays a major role during diabetic
wound healing. Resveratrol (RSV) can promote the polarisation of M2 macrophages and …

Obesity causes low-grade inflammation that results in dyslipidemia and insulin resistance.
We evaluated the effect of puerarin on obesity and metabolic complications both in silico …

Here, we elucidated the structural characteristics of a polysaccharide isolated from Gardenia
jasminoides Ellis (labeled as GP2a) and its immunomodulatory activity. GP2a is an acidic …

Emerging evidence suggests the regulation of microglial phenotype balance between M1
and M2 will be a potential therapeutic strategy for microglia-mediated neuroinflammation in …

Inflammation is an essential defense mechanism in health; however, excessive inflammation
contributes to the pathophysiology of several chronic diseases. Although anti-inflammatory …

Tumor associated macrophages (TAMs) are the predominant innate immune cells in the
tumor microenvironment (TME). Cytokines induce the differentiation of macrophages into …

As total joint replacement is widely applied for severe arthropathy, peri-prosthetic aseptic
loosening as one of the main causes of implant failure has drawn wide attention. Wear …