The metabolome refers to the entire set of small molecules, or metabolites, within a
biological sample. These molecules are involved in many fundamental intracellular …

Unlike the ensemble-averaging measurements, the single-molecule imaging and tracking
(SMIT) in living cells provides the real-time quantitative information about the locations …

The 26S proteasome is a 2.5-MDa multisubunit protease complex that degrades
polyubiquitylated proteins. Although its functions and structure have been extensively …

Label-free optical diffraction tomography provides three-dimensional imaging of cells and
organelles, along with their refractive index (RI) and volume. These physical parameters are …

We describe a general, versatile and minimally invasive method to image single molecules
near the cell surface that can be applied to any GFP-tagged protein in Caenorhabditis …

Bright, long-lasting organic fluorophores enable a broad range of imaging applications.“Self-
healing” fluorophores, in which intra-molecularly linked protective agents quench photo …

Live-cell single-molecule fluorescence imaging has become a powerful analytical tool to
investigate cellular processes that are not accessible to conventional biochemical …

A cell can be viewed as a dynamic puzzle, where single pieces shuffle in space, change
their conformation to fit different partners, and new pieces are generated while old ones are …

Heregulin (HRG) belongs to the family of EGFs and activates the receptor proteins ErbB3
and ErbB4 in a variety of cell types to regulate cell fate. The interactions between HRG and …

Directional neutrophil migration during human immune responses is a highly coordinated
process regulated by both biochemical and biomechanical environments. In this paper, we …