Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase

M Zmudzinski, W Rut, K Olech, J Granda, M Giurg… - Scientific reports, 2023 - nature.com
Proteases encoded by SARS-CoV-2 constitute a promising target for new therapies against
COVID-19. SARS-CoV-2 main protease (Mpro, 3CLpro) and papain-like protease (PLpro) …

Cerium-Doped Manganese Oxide Catalyst for the Oxidative Coupling Synthesis of Fluorescent 2-Amino-1,9-dimethyl-3H-phenoxazin-3-one Using Atmospheric …

F Sun, J Qin, X Cao, X Zhang, X Tang… - ACS Sustainable …, 2022 - ACS Publications
The heterogeneous catalytic oxidative coupling synthesis of 2-amino-3 H-phenoxazin-3-one
(APXO) from the oxidative coupling of 2-aminophenol has important practical significance …

TEMPO-catalyzed electrochemical dehydrogenative cyclocondensation of o-aminophenols: synthesis of aminophenoxazinones as antiproliferative agents

J Zhou, ZY Ma, C Shonhe, SH Ji, YR Cai - Green Chemistry, 2021 - pubs.rsc.org
The aminophenoxazinone core is widely prevalent in natural products, dyes and
pharmaceutical molecules. We report here a TEMPO-catalyzed electrosynthetic method …

Synthesis of aminophenoxazinones and evaluation of their phytotoxicity in the search for new natural herbicides

C Díaz-Franco, C Rial, JMG Molinillo, RM Varela… - Agronomy, 2023 - mdpi.com
Natural products have been postulated as an alternative to the use of synthetic herbicides in
pest control. The latter compounds have caused numerous problems and these include the …

Reaction of bis [(2-chlorocarbonyl) phenyl] diselenide with phenols, aminophenols, and other amines towards diphenyl diselenides with antimicrobial and antiviral …

M Giurg, A Gołąb, J Suchodolski, R Kaleta… - Molecules, 2017 - mdpi.com
A reaction of bis [(2-chlorocarbonyl) phenyl] diselenide with various mono and
bisnucleophiles such as aminophenols, phenols, and amines have been studied as a …

[PDF][PDF] Synthesis of new alkylated and methoxylated analogues of ebselen with antiviral and antimicrobial properties

M Pietka-Ottlik, M Burda-Grabowska, M Wozna… - Arkivoc, 2017 - pdfs.semanticscholar.org
A series of new mono and disubstituted alkylated and methoxylated benzisoselanzol-3 (2H)-
ones and bis (2-carbamoylaryl) diselenides were prepared in yields ranging from 55% to …

Laccase‐Mimicking Syntheses of Phenoxazinones by Aerobic Oxidative Homo‐and Hetero‐Dimerizations of Aminophenols

W Duan, W Li, Q Tang, Y Zhao, X Guo… - ChemistrySelect, 2021 - Wiley Online Library
To pursue a sustainable enzyme‐liking approach, a laccase‐mimicking model that utilized
natural low‐toxic gallic acid as an organocatalyst was developed for efficient aerobic …

Oxidation of 2-aminophenol to 2-amino-3H-phenoxazin-3-one with monochloramine in aqueous environment: A new method for APO synthesis?

O Abou Mehrez, F Dossier-Berne, B Legube - Chemosphere, 2016 - Elsevier
Abstract Reaction of 2-aminophenol (2AP) with monochloramine in aqueous solution was
investigated at pH 8.5 and 25° C, with an excess of monochloramine. 2-Amino-3H …

Silver(I) complex with 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazin-3-one (Phx-1) ligand: crystal structure, vibrational spectra and biological studies

K Helios, H Maniak, M Sowa… - Journal of …, 2017 - Taylor & Francis
The first metal complex of Phx-1 ligand, bis (2-amino-4, 4α-dihydro-4α, 7-dimethyl-3 H-
phenoxazin-3-one) nitratosilver (I),[Ag (Phx-1) 2NO3], has been obtained and investigated …

Expansion of the aromatic part of Cinchona alkaloids. Annulation of quinolines with phenoxazine motifs

M Wąsińska-Kałwa, M Giurg, PJ Boratyński… - Tetrahedron, 2018 - Elsevier
An oxidative cross-coupling strategy for quinoline ring annulation in Cinchona alkaloids has
been developed. Key-reaction optimization by changing oxidants and adjusting the …