Central nervous pathways of insulin action in the control of metabolism and food intake

S Kullmann, A Kleinridders, DM Small… - The lancet Diabetes & …, 2020 - thelancet.com
Insulin acts on the CNS to modulate behaviour and systemic metabolism. Disturbances in
brain insulin action represent a possible link between metabolic and cognitive health …

Interactions between metabolic, reward and cognitive processes in appetite control: Implications for novel weight management therapies

S Higgs, MS Spetter, JM Thomas… - Journal of …, 2017 - journals.sagepub.com
Traditional models of appetite control have emphasised the role of parallel homeostatic and
hedonic systems, but more recently the distinction between independent homeostatic and …

Food insecurity as a driver of obesity in humans: The insurance hypothesis

D Nettle, C Andrews, M Bateson - Behavioral and Brain Sciences, 2017 - cambridge.org
Integrative explanations of why obesity is more prevalent in some sectors of the human
population than others are lacking. Here, we outline and evaluate one candidate …

Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?

ED Barker, A Ing, F Biondo, T Jia, JB **ault… - Molecular …, 2021 - nature.com
There is an extensive body of literature linking ADHD to overweight and obesity. Research
indicates that impulsivity features of ADHD account for a degree of this overlap. The neural …

Neural circuit mechanisms underlying emotional regulation of homeostatic feeding

P Sweeney, Y Yang - Trends in Endocrinology & Metabolism, 2017 - cell.com
The neural circuits controlling feeding and emotional behaviors are intricately and
reciprocally connected. Recent technological developments, including cell type-specific …

Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger

S Kullmann, M Heni, R Veit, K Scheffler, J Machann… - Scientific reports, 2017 - nature.com
Brain insulin sensitivity is an important link between metabolism and cognitive dysfunction.
Intranasal insulin is a promising tool to investigate central insulin action in humans. We …

Bariatric surgery in obese patients reduced resting connectivity of brain regions involved with self‐referential processing

G Li, G Ji, Y Hu, M Xu, Q **, L Liu… - Human Brain …, 2018 - Wiley Online Library
Obese individuals exhibit brain alterations of resting‐state functional connectivity (RSFC)
integrity of resting‐state networks (RSNs) related to food intake. Bariatric surgery is currently …

Structural and functional consequences in the amygdala of leptin-deficient mice

J Schepers, C Gebhardt, A Bracke, I Eiffler… - Cell and Tissue …, 2020 - Springer
On the one hand, the emotional state can influence food intake and on the other hand,
hunger can have an impact on the emotional state. Leptin, which is encoded by the ob gene …

Predicting body mass index from structural MRI brain images using a deep convolutional neural network

P Vakli, RJ Deák-Meszlényi, T Auer… - Frontiers in …, 2020 - frontiersin.org
In recent years, deep learning (DL) has become more widespread in the fields of cognitive
and clinical neuroimaging. Using deep neural network models to process neuroimaging …

Dynamic amygdala nuclei alterations in relation to weight status in anorexia nervosa are mediated by leptin

ML Wronski, F Bernardoni, K Bahnsen, M Seidel… - Journal of the American …, 2024 - Elsevier
Objective The amygdaloid complex is a subcortical limbic group of distinct nuclei. In a
previous patient-control study, differential amygdala nuclei alterations were found in acute …