Airway remodeling in asthma

KP Hough, ML Curtiss, TJ Blain, RM Liu, J Trevor… - Frontiers in …, 2020 - frontiersin.org
Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

Epithelial cell dysfunction, a major driver of asthma development

IH Hei**k, VNS Kuchibhotla, MP Roffel, T Maes… - Allergy, 2020 - Wiley Online Library
Airway epithelial barrier dysfunction is frequently observed in asthma and may have
important implications. The physical barrier function of the airway epithelium is tightly …

Phenotypes and endotypes of adult asthma: moving toward precision medicine

R Kaur, G Chupp - Journal of Allergy and Clinical Immunology, 2019 - Elsevier
Asthma is a chronic inflammatory disease of the airways that is challenging to dissect into
subgroups because of the heterogeneity present across the spectrum of the disease. Efforts …

Advances in bronchiectasis: endoty**, genetics, microbiome, and disease heterogeneity

PA Flume, JD Chalmers, KN Olivier - The Lancet, 2018 - thelancet.com
Bronchiectasis is characterised by pathological dilation of the airways. More specifically, the
radiographic demonstration of airway enlargement is the common feature of a …

Targeting cell signaling in allergic asthma

SS Athari - Signal transduction and targeted therapy, 2019 - nature.com
Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …

Eosinophils from physiology to disease: a comprehensive review

GA Ramirez, MR Yacoub, M Ripa… - BioMed research …, 2018 - Wiley Online Library
Despite being the second least represented granulocyte subpopulation in the circulating
blood, eosinophils are receiving a growing interest from the scientific community, due to their …

Synovial macrophages in osteoarthritis: the key to understanding pathogenesis?

A Thomson, CMU Hilkens - Frontiers in immunology, 2021 - frontiersin.org
Effective treatment of osteoarthritis (OA) remains a huge clinical challenge despite major
research efforts. Different tissues and cell-types within the joint contribute to disease …

Recent advances in understanding the phenotypes of osteoarthritis

A Mobasheri, S Saarakkala, M Finnilä… - …, 2019 - pmc.ncbi.nlm.nih.gov
Recent research in the field of osteoarthritis (OA) has focused on understanding the
underlying molecular and clinical phenotypes of the disease. This narrative review article …

Understanding the key issues in the treatment of uncontrolled persistent asthma with type 2 inflammation

WW Busse, M Kraft, KF Rabe, Y Deniz… - European …, 2021 - publications.ersnet.org
Asthma is a complex respiratory disease that varies in severity and response to treatment.
Several asthma phenotypes with unique clinical and inflammatory characteristics have been …

Toward clinically applicable biomarkers for asthma: an EAACI position paper

Z Diamant, S Vijverberg, K Alving, A Bakirtas… - Allergy, 2019 - Wiley Online Library
Inflammation, structural, and functional abnormalities within the airways are key features of
asthma. Although these processes are well documented, their expression varies across the …