The Interface of Vibrio cholerae and the Gut Microbiome
The bacterium Vibrio cholerae is the etiologic agent of the severe human diarrheal disease
cholera. The gut microbiome, or the native community of microorganisms found in the …
cholera. The gut microbiome, or the native community of microorganisms found in the …
The relevance and potential roles of microphysiological systems in biology and medicine
JP Wikswo - Experimental biology and medicine, 2014 - journals.sagepub.com
Microphysiological systems (MPS), consisting of interacting organs-on-chips or tissue-
engineered, 3D organ constructs that use human cells, present an opportunity to bring new …
engineered, 3D organ constructs that use human cells, present an opportunity to bring new …
Cholera toxin promotes pathogen acquisition of host-derived nutrients
Vibrio cholerae is the causative agent of cholera, a potentially lethal enteric bacterial
infection. Cholera toxin (CTX), a protein complex that is secreted by V. cholerae, is required …
infection. Cholera toxin (CTX), a protein complex that is secreted by V. cholerae, is required …
Engineering challenges for instrumenting and controlling integrated organ-on-chip systems
The sophistication and success of recently reported microfabricated organs-on-chips and
human organ constructs have made it possible to design scaled and interconnected organ …
human organ constructs have made it possible to design scaled and interconnected organ …
[HTML][HTML] The intersection between host–pathogen interactions and metabolism during Vibrio cholerae infection
SR Dominguez, PN Doan, F Rivera-Chávez - Current Opinion in …, 2024 - Elsevier
Vibrio cholerae (V. cholerae), the etiological agent of cholera, uses cholera toxin (CT) to
cause severe diarrheal disease. Cholera is still a significant cause of mortality worldwide …
cause severe diarrheal disease. Cholera is still a significant cause of mortality worldwide …
Real-time monitoring of cellular bioenergetics with a multianalyte screen-printed electrode
JR McKenzie, AC Cognata, AN Davis… - Analytical …, 2015 - ACS Publications
Real-time monitoring of changes to cellular bioenergetics can provide new insights into
mechanisms of action for disease and toxicity. This work describes the development of a …
mechanisms of action for disease and toxicity. This work describes the development of a …
A bistable, multiport valve enables microformulators creating microclinical analyzers that reveal aberrant glutamate metabolism in astrocytes derived from a tuberous …
DR Miller, DK Schaffer, MD Neely, ES McClain… - Sensors and Actuators B …, 2021 - Elsevier
There is a need for valves and pumps that operate at the microscale with precision and
accuracy, are versatile in their application, and are easily fabricated. To that end, we …
accuracy, are versatile in their application, and are easily fabricated. To that end, we …
Organs-on-chips as bridges for predictive toxicology
The next generation of chemical toxicity testing will use organs-on-chips (OoCs)—3D
cultures of heterotypic cells with appropriate extracellular matrices to better approximate the …
cultures of heterotypic cells with appropriate extracellular matrices to better approximate the …
Multichamber multipotentiostat system for cellular microphysiometry
Multianalyte microphysiometry is a powerful technique for studying cellular metabolic flux in
real time. Monitoring several analytes concurrently in a number of individual chambers …
real time. Monitoring several analytes concurrently in a number of individual chambers …
Metabolic multianalyte microphysiometry reveals extracellular acidosis is an essential mediator of neuronal preconditioning
Metabolic adaptation to stress is a crucial yet poorly understood phenomenon, particularly in
the central nervous system (CNS). The ability to identify essential metabolic events which …
the central nervous system (CNS). The ability to identify essential metabolic events which …