Chemoprevention strategies reduce malaria disease and death, but the efficacy of anti-
malarial drugs used for chemoprevention is perennially threatened by drug resistance. This …

One hundred and twenty-five million women in malaria-endemic areas become pregnant
each year (see Dellicour et al. PLoS Med 7: e1000221 [2010]) and require protection from …

Background. The emergence of artemisinin-resistant Plasmodium falciparum in Southeast
Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P …

Mechanisms of action (MoAs) have been elusive for most antimalarial drugs in clinical use.
Decreasing responsiveness to antimalarial treatments stresses the need for a better …

In 1993, Malawi became the first African country to replace chloroquine with sulfadoxine-
pyrimethamine nationwide in response to high rates of chloroquine-resistant falciparum …

Approximately 40% of the world population live in areas with the risk of malaria. Each year,
300–500 million people suffer from acute malaria, and 0.5–2.5 million die from the disease …

Despite considerable efforts, malaria is still one of the most devastating infectious diseases
in the tropics. The rapid spread of antimalarial drug resistance currently compounds this …

Summary Background Resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine
threatens the antimalarial effectiveness of intermittent preventive treatment during …

Sulfadoxine–pyrimethamine (SP) is used throughout Africa for intermittent preventive
treatment (IPT) of malaria, but resistance threatens its efficacy. We found marked regional …

New drugs against malaria are greatly needed. Many approaches to antimalarial drug
discovery are available. These approaches must take into account specific concerns, in …