The finding that small non-coding RNAs (ncRNAs) are able to control gene expression in a
sequence specific manner has had a massive impact on biology. Recent improvements in …

R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …

R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …

RNA: DNA hybrid structures known as R loops were thought to be rare byproducts of
transcription. In the last decade, however, accumulating evidence has pointed to a new view …

CpG islands (CGIs) function as promoters for approximately 60% of human genes. Most of
these elements remain protected from CpG methylation, a prevalent epigenetic modification …

R loops are three-stranded nucleic acid structures that comprise nascent RNA hybridized
with the DNA template, leaving the nontemplate DNA single-stranded. R loops form naturally …

Polyamines are essential for the growth and function of normal cells. They interact with
various macromolecules, both electrostatically and covalently and, as a consequence, have …

PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …

A DNA triplex is formed when pyrimidine or purine bases occupy the major groove of the
DNA double Helix forming Hoogsteen pairs with purines of the Watson-Crick basepairs …

The mechanism responsible for immunoglobulin class switch recombination is unknown.
Previous work has shown that class switch sequences have the unusual property of forming …