Iron is an essential element in biology, required for numerous cellular processes. Either too
much or too little iron can be detrimental, and organisms have developed mechanisms for …

Iron has the capacity to accept and donate electrons readily, interconverting between ferric
(Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of …

Iron is vital for almost all living organisms by participating in a wide variety of metabolic
processes, including oxygen transport, DNA synthesis, and electron transport. However, iron …

Iron is an essential nutrient with limited bioavailability. When present in excess, iron poses a
threat to cells and tissues, and therefore iron homeostasis has to be tightly controlled. Iron's …

For many years, hereditary hemochromatosis was regarded as a clinically and genetically
unique entity marked by a classic presentation consisting of diabetes, bronze skin …

Juvenile hemochromatosis is an early-onset autosomal recessive disorder of iron overload
resulting in cardiomyopathy, diabetes and hypogonadism that presents in the teens and …

Animal models indicate that the antimicrobial peptide hepcidin (HAMP; OMIM 606464) is
probably a key regulator of iron absorption in mammals. Here we report the identification of …

Haemochromatosis is a common recessive disorder characterized by progressive iron
overload, which may lead to severe clinical complications. Most patients are homozygous for …

Disorders that perturb iron balance are among the most prevalent human diseases, but until
recently iron transport remained poorly understood. Over the past five years, genetic studies …

Hereditary hemochromatosis (HHC) is an autosomal recessive disorder of iron metabolism
characterized by increased iron absorption and deposition in the liver, pancreas, heart …