The accumulation of unfolded proteins in the endoplasmic reticulum (ER) represents a
cellular stress induced by multiple stimuli and pathological conditions. These include …

The HSPA5 gene encodes the binding immunoglobulin protein (BiP), an Hsp70 family
chaperone localized in the ER lumen. As a highly conserved molecular chaperone, BiP …

Proteins requiring post‐translational modifications such as N‐linked glycosylation are
processed in the endoplasmic reticulum (ER). A diverse array of cellular stresses can lead to …

Many exogenous sources of stress can lead to cell death. In recent years, endogenous
cellular sources of stress have also been identified, including the stress that arises from the …

Immune responses to certain heat-shock proteins (HSPs) develop in almost all inflammatory
diseases; however, the significance of such responses is only now becoming clear. In …

The diagnosis of rheumatoid arthritis (RA) is primarily based on clinical symptoms, so it is
often difficult to diagnose RA in very early stages of the disease. A disease-specific …

Objective To explore the changes in serologic variables and clinical disease activity
following B lymphocyte depletion in 22 patients with rheumatoid arthritis (RA). Methods B …

Objectives: To determine the frequency of antibodies to cyclic citrullinated peptides (CCP) in
a group of patients with a diversity of rheumatic diseases. Methods: 249 consecutive sera …

Objective To examine the association between aberrant IgG galactosylation and disease
parameters in rheumatoid arthritis (RA). Methods Analysis of N‐glycan in serum samples …

Heat shock proteins (HSPs) have been reported to stimulate the immune system via innate
receptors. However, the role of HSPs as endogenous adjuvants has been challenged by …