Using MetaboAnalyst 5.0 for LC–HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data

Z Pang, G Zhou, J Ewald, L Chang, O Hacariz… - Nature protocols, 2022‏ - nature.com
Liquid chromatography coupled with high-resolution mass spectrometry (LC–HRMS) has
become a workhorse in global metabolomics studies with growing applications across …

Guide to metabolomics analysis: a bioinformatics workflow

Y Chen, EM Li, LY Xu - Metabolites, 2022‏ - mdpi.com
Metabolomics is an emerging field that quantifies numerous metabolites systematically. The
key purpose of metabolomics is to identify the metabolites corresponding to each biological …

Comprehensive investigation of pathway enrichment methods for functional interpretation of LC–MS global metabolomics data

Y Lu, Z Pang, J **a - Briefings in Bioinformatics, 2023‏ - academic.oup.com
Background: Global or untargeted metabolomics is widely used to comprehensively
investigate metabolic profiles under various pathophysiological conditions such as …

[HTML][HTML] MetaboAnalystR 3.0: toward an optimized workflow for global metabolomics

Z Pang, J Chong, S Li, J **a - Metabolites, 2020‏ - mdpi.com
Liquid chromatography coupled to high-resolution mass spectrometry platforms are
increasingly employed to comprehensively measure metabolome changes in systems …

Recent advances in the application of metabolomics for food safety control and food quality analyses

S Li, Y Tian, P Jiang, Y Lin, X Liu… - Critical reviews in food …, 2021‏ - Taylor & Francis
As one of the omics fields, metabolomics has unique advantages in facilitating the
understanding of physiological and pathological activities in biology, physiology, pathology …

Metabolic reaction network-based recursive metabolite annotation for untargeted metabolomics

X Shen, R Wang, X **ong, Y Yin, Y Cai, Z Ma… - Nature …, 2019‏ - nature.com
Large-scale metabolite annotation is a challenge in liquid chromatogram-mass spectrometry
(LC-MS)-based untargeted metabolomics. Here, we develop a metabolic reaction network …

Advanced analytical and informatic strategies for metabolite annotation in untargeted metabolomics

Y Cai, Z Zhou, ZJ Zhu - TrAC Trends in Analytical Chemistry, 2023‏ - Elsevier
Liquid chromatography–mass spectrometry (LC–MS)-based untargeted metabolomics is
constantly challenged by large-scale and unambiguous metabolite annotation in complex …

Plasmonic alloys reveal a distinct metabolic phenotype of early gastric cancer

H Su, X Li, L Huang, J Cao, M Zhang… - Advanced …, 2021‏ - Wiley Online Library
Gastric cancer (GC) is a multifactorial process, accompanied by alterations in metabolic
pathways. Non‐invasive metabolic profiling facilitates GC diagnosis at early stage leading to …

Ensuring fact-based metabolite identification in liquid chromatography–mass spectrometry-based metabolomics

G Theodoridis, H Gika, D Raftery, R Goodacre… - Analytical …, 2023‏ - ACS Publications
Metabolite identification represents a major bottleneck in contemporary metabolomics
research and a step where critical errors may occur and pass unnoticed. This is especially …

Recent advances in proteomics and metabolomics in plants

S Yan, R Bhawal, Z Yin, TW Thannhauser… - Molecular Horticulture, 2022‏ - Springer
Over the past decade, systems biology and plant-omics have increasingly become the main
stream in plant biology research. New developments in mass spectrometry and …