GABAA receptors: structure, function, pharmacology, and related disorders
Background γ-Aminobutyric acid sub-type A receptors (GABAARs) are the most prominent
inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion …
inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion …
GABAA receptors and the diversity in their structure and pharmacology
Abstract GABA A receptors (GABA A Rs) are a class of ligand-gated ion channels with high
physiological and therapeutic significance. In the brain, these pentameric receptors occur …
physiological and therapeutic significance. In the brain, these pentameric receptors occur …
EMC rectifies the topology of multipass membrane proteins
Most eukaryotic multipass membrane proteins are inserted into the membrane of the
endoplasmic reticulum. Their transmembrane domains (TMDs) are thought to be inserted co …
endoplasmic reticulum. Their transmembrane domains (TMDs) are thought to be inserted co …
Genomic landscape of drug response reveals mediators of anthelmintic resistance
Like other pathogens, parasitic helminths can rapidly evolve resistance to drug treatment.
Understanding the genetic basis of anthelmintic drug resistance in parasitic nematodes is …
Understanding the genetic basis of anthelmintic drug resistance in parasitic nematodes is …
Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA
Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by
GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop …
GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop …
Highlighting membrane protein structure and function: A celebration of the Protein Data Bank
Biological membranes define the boundaries of cells and compartmentalize the chemical
and physical processes required for life. Many biological processes are carried out by …
and physical processes required for life. Many biological processes are carried out by …
Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators
The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that
modulates neuronal excitability, largely by allowing Ca2+ permeation. Agonist binding …
modulates neuronal excitability, largely by allowing Ca2+ permeation. Agonist binding …
Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What?
R Puthenkalam, M Hieckel, X Simeone… - Frontiers in molecular …, 2016 - frontiersin.org
Atomic resolution structures of cys-loop receptors, including one of a γ-aminobutyric acid
type A receptor (GABAA receptor) subtype, allow amazing insights into the structural …
type A receptor (GABAA receptor) subtype, allow amazing insights into the structural …
Organization of circadian behavior relies on glycinergic transmission
The small ventral lateral neurons (sLNvs) constitute a central circadian pacemaker in the
Drosophila brain. They organize daily locomotor activity, partly through the release of the …
Drosophila brain. They organize daily locomotor activity, partly through the release of the …
[HTML][HTML] Elephants in the dark: insights and incongruities in pentameric ligand-gated ion channel models
RJ Howard - Journal of Molecular Biology, 2021 - Elsevier
The superfamily of pentameric ligand-gated ion channels (pLGICs) comprises key players in
electrochemical signal transduction across evolution, including historic model systems for …
electrochemical signal transduction across evolution, including historic model systems for …