Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Zinc is a micronutrient of key importance for human health. An increasing number of studies
indicate that zinc plays a significant role in bone tissue's normal development and …

Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …

Zinc is a trace metal ion in the central nervous system that plays important biological roles,
such as in catalysis, structure, and regulation. It contributes to antioxidant function and the …

Zinc is a crucial trace element in the human body, playing a role in various physiological
processes such as oxidative stress, neurotransmission, protein synthesis, and DNA repair …

The importance of coenzyme A (CoA) as a carrier of acyl residues in cell metabolism is well
understood. Coenzyme A participates in more than 100 different catabolic and anabolic …

N-methyl-d-aspartate receptors (NMDARs) are transmembrane proteins that are activated by
the neurotransmitter glutamate and are found at most excitatory vertebrate synapses …

Summary N-methyl-D-aspartate (NMDA) receptors are glutamate-gated calcium-permeable
ion channels that are widely implicated in synaptic transmission and plasticity. Here, we …