Immune responses against cancer are dominated by T cell exhaustion and dysfunction.
Recent advances have underscored the critical role of early priming interactions in …

Non-small cell lung cancer (NSCLC) remains an unsolved challenge in oncology, signifying
a substantial global health burden. While considerable progress has been made in recent …

Cytokines are proteins used by immune cells to communicate with each other and with cells
in their environment. The pleiotropic effects of cytokine networks are determined by which …

Tumor cell–intrinsic signaling pathways can drastically affect the tumor immune
microenvironment, promoting tumor progression and resistance to immunotherapy by …

Highlights•Serum albumin (SA) enhances pharmacokinetic properties of small
immunomodulatory payloads (IMMs).•SA can traffic efficiently to the lymphatics and thus …

Anti-PD1 immune checkpoint blockade (ICB) has shown promising results for treating
several aggressive cancers, enhancing patient survival rates. The variability in clinical …

Breast cancer remains a significant health challenge worldwide, with substantial efforts
aimed at understanding its pathogenesis, biological characteristics, and clinical triggers …

Effective cancer therapies must address the tumor microenvironment (TME), a complex
network of tumor cells and stromal components, including endothelial, immune, and …

Identification of accurate biomarkers is still particularly urgent for improving the poor survival
of chronic obstructive pulmonary disease (COPD) patients. In this investigation, we aimed to …