Despite decades of research, brain tumours remain among the deadliest of all forms of
cancer. The ability of these tumours to resist almost all conventional and novel treatments …

Glioblastoma (WHO grade IV astrocytoma) is the most frequent primary brain tumor in adults,
representing a highly heterogeneous group of neoplasms that are among the most …

Background Gastric cancer (GC) is one of the most pernicious tumors that seriously harm
human healthcare. GC metastasis is one of the prime cause of failed cancer treatment, but …

We test the hypothesis that glioblastoma harbors quiescent cancer stem cells that evade anti-
proliferative therapies. Functional characterization of spontaneous glioblastomas from …

Genome-wide screening using CRISPR coupled with nuclease Cas9 (CRISPR–Cas9) is a
powerful technology for the systematic evaluation of gene function. Statistically principled …

The genetic dependencies of human cancers widely vary. Here, we catalog this
heterogeneity and use it to identify functional gene interactions and genotype-dependent …

Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis,
thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an …

Protein phosphorylation is a major regulator of protein function and biological outcomes.
This was first recognized through functional biochemical experiments, and in the past …

Intratumoral heterogeneity (ITH) has increasingly being described for multiple cancers as
the root cause of therapy resistance. Recent studies have started to explore the scope of ITH …

Background Non-small cell lung cancer (NSCLC) is the most common type of human lung
cancers, which has diverse pathological features. Although many signaling pathways and …