Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease
Chronic kidney disease (CKD), defined as persistent (> 3 months) kidney functional loss,
has a growing prevalence (> 10% worldwide population) and limited treatment options …
has a growing prevalence (> 10% worldwide population) and limited treatment options …
Estrogen sulfotransferase and sulfatase in steroid homeostasis, metabolic disease, and cancer
J Wang, Y Feng, B Liu, W **e - Steroids, 2024 - Elsevier
Sulfation and desulfation of steroids are opposing processes that regulate the activation,
metabolism, excretion, and storage of steroids, which account for steroid homeostasis …
metabolism, excretion, and storage of steroids, which account for steroid homeostasis …
[HTML][HTML] Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy
C Chu, X Wang, C Yang, F Chen, L Shi, W Xu, K Wang… - Redox Biology, 2023 - Elsevier
Microvascular endothelial damage caused by intestinal ischemia‒reperfusion (II/R) is a
primary catalyst for microcirculation dysfunction and enterogenous infection. Previous …
primary catalyst for microcirculation dysfunction and enterogenous infection. Previous …
The alteration of drug metabolism enzymes and pharmacokinetic parameters in nonalcoholic fatty liver disease: current animal models and clinical practice
Y Zhu, L Chen, Y He, L Qin, D Tan, Z Bai… - Drug Metabolism …, 2023 - Taylor & Francis
Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease. The whole
concept of NAFLD has now moved into metabolic dysfunction-associated fatty liver disease …
concept of NAFLD has now moved into metabolic dysfunction-associated fatty liver disease …
Oxysterol misbalance critically contributes to Wilson disease pathogenesis
Wilson disease (WD) is a metabolic disorder caused by inactivation of the copper-
transporting ATPase 2 (ATP7B) and copper (Cu) overload in tissues. Excess Cu causes …
transporting ATPase 2 (ATP7B) and copper (Cu) overload in tissues. Excess Cu causes …
Vitamin D and acute kidney injury: A two-way causality relation and a predictive, prognostic, and therapeutic role of vitamin D
Background: Acute kidney injury (AKI) constitutes a multi-factorially caused condition, which
significantly affects kidney function and can lead to elevated risk of morbidity and mortality …
significantly affects kidney function and can lead to elevated risk of morbidity and mortality …
Integrated metabolomics and transcriptomics revealed the anti-constipation mechanisms of xylooligosaccharides from corn cobs
H Song, R Guo, X Sun, Y Kou, X Ma, Y Chen, L Song… - Food & Function, 2024 - pubs.rsc.org
Xylooligosaccharides (XOSs) have recently garnered interest for their potential as an anti-
constipation agent. In this study, we investigated the effects of XOSs derived from corn cobs …
constipation agent. In this study, we investigated the effects of XOSs derived from corn cobs …
Role of epigenetically regulated inflammation in renal diseases
J **, Y Yang, Q Gong, J Wang, W Ni, J Wen… - Seminars in Cell & …, 2024 - Elsevier
In recent decades, renal disease research has witnessed remarkable advances.
Experimental evidence in this field has highlighted the role of inflammation in kidney …
Experimental evidence in this field has highlighted the role of inflammation in kidney …
Hepatocyte estrogen sulfotransferase inhibition protects female mice from concanavalin A–induced T cell–mediated hepatitis independent of estrogens
Autoimmune hepatitis (AIH) is a typical T cell–mediated chronic liver disease with a higher
incidence in females. However, the molecular mechanism for the female predisposition is …
incidence in females. However, the molecular mechanism for the female predisposition is …
Metabolism and bioenergetics in the pathophysiology of organ fibrosis
V Miguel, E Alcalde-Estévez, B Sirera… - Free Radical Biology …, 2024 - Elsevier
Fibrosis is the tissue scarring characterized by excess deposition of extracellular matrix
(ECM) proteins, mainly collagens. A fibrotic response can take place in any tissue of the …
(ECM) proteins, mainly collagens. A fibrotic response can take place in any tissue of the …