Progress of microfluidic hydrogel‐based scaffolds and organ‐on‐chips for the cartilage tissue engineering
Cartilage degeneration is among the fundamental reasons behind disability and pain across
the globe. Numerous approaches have been employed to treat cartilage diseases …
the globe. Numerous approaches have been employed to treat cartilage diseases …
[HTML][HTML] Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms
S Chen, D Gan, S Lin, Y Zhong, M Chen, X Zou… - Theranostics, 2022 - ncbi.nlm.nih.gov
Aging is a natural process, which plays a critical role in the pathogenesis of a variety of
diseases, ie, aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease …
diseases, ie, aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease …
Osteoarthritis: New insight on its pathophysiology
Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements
in recent years. It has been observed that cartilage degeneration is preceded by …
in recent years. It has been observed that cartilage degeneration is preceded by …
Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis
Z Liu, Y Zhuang, L Fang, C Yuan, X Wang… - Bioactive …, 2022 - pmc.ncbi.nlm.nih.gov
Osteoarthritis (OA) is a highly prevalent whole-joint disease that causes disability and pain
and affects a patient's quality of life. However, currently, there is a lack of effective early …
and affects a patient's quality of life. However, currently, there is a lack of effective early …
Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to …
H Zhou, X Shen, C Yan, W **ong, Z Ma, Z Tan… - Stem Cell Research & …, 2022 - Springer
Background Osteoarthritis (OA) is a prevalent degenerative joint disease that not only
significantly impairs the quality of life of middle-aged and elderly individuals but also …
significantly impairs the quality of life of middle-aged and elderly individuals but also …
Exosome-transported circRNA_0001236 enhances chondrogenesis and suppress cartilage degradation via the miR-3677-3p/Sox9 axis
G Mao, Y Xu, D Long, H Sun, H Li, R **n… - Stem Cell Research & …, 2021 - Springer
Objectives Aberrations in exosomal circular RNA (circRNA) expression have been identified
in various human diseases. In this study, we investigated whether exosomal circRNAs could …
in various human diseases. In this study, we investigated whether exosomal circRNAs could …
Exosomes derived from hypoxia-cultured human adipose stem cells alleviate articular chondrocyte inflammaging and post-traumatic osteoarthritis progression
Osteoarthritis (OA) is the most common age-related degenerative joint disease.
Inflammaging, linking inflammation and aging, is found in senescent cells with the secretions …
Inflammaging, linking inflammation and aging, is found in senescent cells with the secretions …
Mitophagy—a new target of bone disease
Z Zeng, X Zhou, Y Wang, H Cao, J Guo, P Wang… - Biomolecules, 2022 - mdpi.com
Bone diseases are usually caused by abnormal metabolism and death of cells in bones,
including osteoblasts, osteoclasts, osteocytes, chondrocytes, and bone marrow …
including osteoblasts, osteoclasts, osteocytes, chondrocytes, and bone marrow …
Stimulus‐Responsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy
Q Jiang, S Zhang - Small, 2023 - Wiley Online Library
Osteoarthritis (OA) is one of the most prevalent age‐related degenerative diseases. With an
increasingly aging global population, greater numbers of OA patients are providing clear …
increasingly aging global population, greater numbers of OA patients are providing clear …
Impaired efferocytosis by synovial macrophages in patients with knee osteoarthritis
L Del Sordo, GB Blackler, HT Philpott… - Arthritis & …, 2023 - Wiley Online Library
Objective Osteoarthritis (OA) exposes all joint tissues to physiologic stresses, increasing the
need to clear apoptotic cells from tissues, including the synovium. We undertook this study to …
need to clear apoptotic cells from tissues, including the synovium. We undertook this study to …