Progress of microfluidic hydrogel‐based scaffolds and organ‐on‐chips for the cartilage tissue engineering

H Tolabi, N Davari, M Khajehmohammadi… - Advanced …, 2023 - Wiley Online Library
Cartilage degeneration is among the fundamental reasons behind disability and pain across
the globe. Numerous approaches have been employed to treat cartilage diseases …

[HTML][HTML] Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms

S Chen, D Gan, S Lin, Y Zhong, M Chen, X Zou… - Theranostics, 2022 - ncbi.nlm.nih.gov
Aging is a natural process, which plays a critical role in the pathogenesis of a variety of
diseases, ie, aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease …

Osteoarthritis: New insight on its pathophysiology

S Coaccioli, P Sarzi-Puttini, P Zis, G Rinonapoli… - Journal of Clinical …, 2022 - mdpi.com
Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements
in recent years. It has been observed that cartilage degeneration is preceded by …

Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis

Z Liu, Y Zhuang, L Fang, C Yuan, X Wang… - Bioactive …, 2022 - pmc.ncbi.nlm.nih.gov
Osteoarthritis (OA) is a highly prevalent whole-joint disease that causes disability and pain
and affects a patient's quality of life. However, currently, there is a lack of effective early …

Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to …

H Zhou, X Shen, C Yan, W **ong, Z Ma, Z Tan… - Stem Cell Research & …, 2022 - Springer
Background Osteoarthritis (OA) is a prevalent degenerative joint disease that not only
significantly impairs the quality of life of middle-aged and elderly individuals but also …

Exosome-transported circRNA_0001236 enhances chondrogenesis and suppress cartilage degradation via the miR-3677-3p/Sox9 axis

G Mao, Y Xu, D Long, H Sun, H Li, R **n… - Stem Cell Research & …, 2021 - Springer
Objectives Aberrations in exosomal circular RNA (circRNA) expression have been identified
in various human diseases. In this study, we investigated whether exosomal circRNAs could …

Exosomes derived from hypoxia-cultured human adipose stem cells alleviate articular chondrocyte inflammaging and post-traumatic osteoarthritis progression

LH Chang, SC Wu, CH Chen, JW Chen… - International Journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is the most common age-related degenerative joint disease.
Inflammaging, linking inflammation and aging, is found in senescent cells with the secretions …

Mitophagy—a new target of bone disease

Z Zeng, X Zhou, Y Wang, H Cao, J Guo, P Wang… - Biomolecules, 2022 - mdpi.com
Bone diseases are usually caused by abnormal metabolism and death of cells in bones,
including osteoblasts, osteoclasts, osteocytes, chondrocytes, and bone marrow …

Stimulus‐Responsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy

Q Jiang, S Zhang - Small, 2023 - Wiley Online Library
Osteoarthritis (OA) is one of the most prevalent age‐related degenerative diseases. With an
increasingly aging global population, greater numbers of OA patients are providing clear …

Impaired efferocytosis by synovial macrophages in patients with knee osteoarthritis

L Del Sordo, GB Blackler, HT Philpott… - Arthritis & …, 2023 - Wiley Online Library
Objective Osteoarthritis (OA) exposes all joint tissues to physiologic stresses, increasing the
need to clear apoptotic cells from tissues, including the synovium. We undertook this study to …