Nuclear factor kappa B (NF-κB) transcription factors regulate several important physiological
processes, including inflammation and immune responses, cell growth, apoptosis, and the …

Hodgkin's lymphoma (HL) represents the most common subtype of malignant lymphoma in
young people in the Western world. Most patients can be cured with modern treatment …

The cytotoxicity of chemotherapeutic agents is attributed to apoptosis. Acquired resistance to
the effects of chemotherapy has emerged as a significant impediment to effective cancer …

Bortezomib (Velcade, formerly known as PS-341) is a boronic acid dipeptide derivative that
is a selective and potent inhibitor of the proteasome. We hypothesized that proteasome …

The proteasome inhibitor bortezomib (formerly known as PS-341) recently received Food
and Drug Administration approval for the treatment of multiple myeloma, and its activity is …

The 26S proteasome has a direct impact on cellular transcription regulation, cell-cycle
progression, oncogenesis and apoptosis, since the turnover of the vast majority of …

Background Curcumin is a polyphenolic compound isolated from the rhizomes of the
plantCurcuma longa and shows intrinsic anti-cancer properties. Its medical useremains …

Melanoma is the most aggressive form of skin cancer and advanced stages are invariably
resistant to conventional therapeutic agents. Using bortezomib as a prototypic proteasome …

The tumor cells that drive classical Hodgkin lymphoma (cHL), namely, Hodgkin and Reed-
Sternberg (HRS) cells, display hallmark features that include their rareness in contrast with …

Classical Hodgkin lymphoma (cHL) is characterized by few tumor cells surrounded by
immune cells, fibroblasts, specialized mesenchymal stromal cells and endothelial cells …