The journey from melanocytes to melanoma

PP Centeno, V Pavet, R Marais - Nature Reviews Cancer, 2023 - nature.com
Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …

Clinical and biological characterization of skin pigmentation diversity and its consequences on UV impact

S Del Bino, C Duval, F Bernerd - International journal of molecular …, 2018 - mdpi.com
Skin color diversity is the most variable and noticeable phenotypic trait in humans resulting
from constitutive pigmentation variability. This paper will review the characterization of skin …

Loci associated with skin pigmentation identified in African populations

NG Crawford, DE Kelly, MEB Hansen, MH Beltrame… - Science, 2017 - science.org
INTRODUCTION Variation in pigmentation among human populations may reflect local
adaptation to regional light environments, because dark skin is more photoprotective …

[HTML][HTML] The genomic origins of the world's first farmers

N Marchi, L Winkelbach, I Schulz, M Brami… - Cell, 2022 - cell.com
The precise genetic origins of the first Neolithic farming populations in Europe and
Southwest Asia, as well as the processes and the timing of their differentiation, remain …

[HTML][HTML] The HIrisPlex system for simultaneous prediction of hair and eye colour from DNA

S Walsh, F Liu, A Wollstein, L Kovatsi, A Ralf… - Forensic Science …, 2013 - Elsevier
Recently, the field of predicting phenotypes of externally visible characteristics (EVCs) from
DNA genotypes with the final aim of concentrating police investigations to find persons …

Human skin pigmentation as an adaptation to UV radiation

NG Jablonski, G Chaplin - Proceedings of the National …, 2010 - National Acad Sciences
Human skin pigmentation is the product of two clines produced by natural selection to adjust
levels of constitutive pigmentation to levels of UV radiation (UVR). One cline was generated …

Melanocyte biology and skin pigmentation

JY Lin, DE Fisher - Nature, 2007 - nature.com
Melanocytes are phenotypically prominent but histologically inconspicuous skin cells. They
are responsible for the pigmentation of skin and hair, and thereby contribute to the …

[HTML][HTML] The contribution of Neanderthals to phenotypic variation in modern humans

M Dannemann, J Kelso - The American journal of human genetics, 2017 - cell.com
Assessing the genetic contribution of Neanderthals to non-disease phenotypes in modern
humans has been difficult because of the absence of large cohorts for which common …

Genetic determinants of hair, eye and skin pigmentation in Europeans

P Sulem, DF Gudbjartsson, SN Stacey, A Helgason… - Nature …, 2007 - nature.com
Hair, skin and eye colors are highly heritable and visible traits in humans. We carried out a
genome-wide association scan for variants associated with hair and eye pigmentation, skin …

[LIBRO][B] Human evolutionary genetics: origins, peoples and disease

M Jobling, C Tyler-Smith - 2019 - taylorfrancis.com
Human Evolutionary Genetics is a groundbreaking text which for the first time brings
together molecular genetics and genomics to the study of the origins and movements of …