Hypoglycaemia in diabetes mellitus: epidemiology and clinical implications

BM Frier - Nature Reviews Endocrinology, 2014 - nature.com
Hypoglycaemia is a frequent adverse effect of treatment of diabetes mellitus with insulin and
sulphonylureas. Fear of hypoglycaemia alters self-management of diabetes mellitus and …

Hypoglycemia: The neglected complication

S Kalra, JJ Mukherjee, S Venkataraman… - Indian journal of …, 2013 - journals.lww.com
Hypoglycemia is an important complication of glucose-lowering therapy in patients with
diabetes mellitus. Attempts made at intensive glycemic control invariably increases the risk …

Effect of insulin degludec vs insulin glargine U100 on hypoglycemia in patients with type 2 diabetes: the SWITCH 2 randomized clinical trial

C Wysham, A Bhargava, L Chaykin, R de la Rosa… - Jama, 2017 - jamanetwork.com
Importance Hypoglycemia, a serious risk for insulin-treated patients with type 2 diabetes,
negatively affects glycemic control. Objective To test whether treatment with basal insulin …

Patient‐level meta‐analysis of the EDITION 1, 2 and 3 studies: glycaemic control and hypoglycaemia with new insulin glargine 300 U/ml versus glargine 100 U/ml in …

R Ritzel, R Roussel, GB Bolli, L Vinet… - Diabetes, Obesity …, 2015 - Wiley Online Library
Aims To conduct a patient‐level meta‐analysis of the EDITION 1, 2 and 3 studies, which
compared the efficacy and safety of new insulin glargine 300 U/ml (G la‐300) with insulin …

Weight loss associated with sodium‐glucose cotransporter‐2 inhibition: a review of evidence and underlying mechanisms

PC Lee, S Ganguly, SY Goh - Obesity Reviews, 2018 - Wiley Online Library
With their novel, insulin‐independent mechanism, sodium‐glucose cotransporter‐2 (SGLT2)
inhibitors are a major turning point in the management of type 2 diabetes mellitus. At …

Effect of insulin degludec vs insulin glargine U100 on hypoglycemia in patients with type 1 diabetes: the SWITCH 1 randomized clinical trial

W Lane, TS Bailey, G Gerety, J Gumprecht… - Jama, 2017 - jamanetwork.com
Importance Hypoglycemia, common in patients with type 1 diabetes, is a major barrier to
achieving good glycemic control. Severe hypoglycemia can lead to coma or death. Objective …

Prevalence and incidence of hypoglycaemia in 532,542 people with type 2 diabetes on oral therapies and insulin: a systematic review and meta-analysis of …

CL Edridge, AJ Dunkley, DH Bodicoat, TC Rose… - PloS one, 2015 - journals.plos.org
Objective To collate and evaluate the current literature reporting the prevalence and
incidence of hypoglycaemia in population based studies of type 2 diabetes. Research …

Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: a 1-year, randomized, treat-to-target trial (BEGIN Once Long)

B Zinman, A Philis-Tsimikas, B Cariou… - Diabetes …, 2012 - diabetesjournals.org
OBJECTIVE To compare ultra-long-acting insulin degludec with glargine for efficacy and
safety in insulin-naive patients with type 2 diabetes inadequately controlled with oral …

A review of the pharmacological properties of insulin degludec and their clinical relevance

H Haahr, T Heise - Clinical pharmacokinetics, 2014 - Springer
Insulin degludec (IDeg) is a new-generation basal insulin with an ultra-long duration of
action. To date, a large number of studies have been conducted to investigate the …

Hypoglycaemia in type 2 diabetes

SA Amiel, T Dixon, R Mann, K Jameson - Diabetic medicine, 2008 - Wiley Online Library
The primary cause of hypoglycaemia in Type 2 diabetes is diabetes medication—in
particular, those which raise insulin levels independently of blood glucose, such as …