Binding, gating, a nity and e cacy Page 1 SEMINAR Binding, gating, a nity and e cacy The nature
of the problem Some history The classical era The interaction between binding and conformation …

Publisher Summary The chapter describes the understanding of the physics and physical
chemistry of sickle cell hemoglobin polymerization in solutions and in red cells. The …

Methylation of arginine (Arg) and lysine residues in histones has been correlated with
epigenetic forms of gene regulation. Although histone methyltransferases are known …

The structural changes that occur on ligand binding to haemoglobin have been studied by
comparison of the atomic co-ordinates of human deoxy, horse met and human …

Riboswitches are structured elements typically found in the 5′ untranslated regions of
mRNAs, where they regulate gene expression by binding to small metabolites. In all …

We identified a previously unknown riboswitch class in bacteria that is selectively triggered
by glycine. A representative of these glycine-sensing RNAs from Bacillus subtilis operates …

We report a rational design of CaHPO4-α-amylase hybrid nanobiocatalytic system based on
allosteric effect and an explanation of the increase in catalytic activity when certain enzymes …

France rather than the tertiary folding within each individual subunit. In other words, the
cooperative interactions The concept of allosteric proteins was initially proposed between …

Using a combination of laser photolysis and temperature-jump techniques, the kinetics of
hemoglobin S polymerization have been studied over a wide range of delay times (10− 3 to …

We have stably expressed in fibroblasts different pairs of a and non-a subunits of the mouse
muscle nicotinic acetylcholine receptor (AChR). They and 6, but not the B, subunits …