The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …

Cognitive dysfunctions such as mild cognitive impairment (MCI), Alzheimer's disease (AD),
and other forms of dementia are recognized as common comorbidities of type 2 diabetes …

Background: Type 2 diabetes mellitus (T2DM) is known to be associated with
neurobiological and cognitive deficits; however, their extent, overlap with aging effects, and …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Both type 1 and type 2 diabetes have been associated with reduced performance on
multiple domains of cognitive function and with structural abnormalities in the brain. With an …

The literature on large‐scale resting‐state functional brain networks across the adult
lifespan was systematically reviewed. Studies published between 1986 and July 2021 were …

Diabetic peripheral neuropathy (DPN) affects up to 50% of patients with diabetes and is a
major cause of morbidity and increased mortality. Its clinical manifestations include painful …

Insulin performs unique functions within the CNS. Produced nearly exclusively by the
pancreas, insulin crosses the blood–brain barrier (BBB) using a saturable transporter …

OBJECTIVE Type 2 diabetes (T2DM) is associated with brain atrophy and cerebrovascular
disease. We aimed to define the regional distribution of brain atrophy in T2DM and to …