Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …
Phosphoinositides: tiny lipids with giant impact on cell regulation
T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia
We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We …
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We …
GSK3: a multifaceted kinase in Wnt signaling
D Wu, W Pan - Trends in biochemical sciences, 2010 - cell.com
GSK3 is one of the few signaling mediators that play central roles in a diverse range of
signaling pathways, including those activated by Wnts, hedgehog, growth factors, cytokines …
signaling pathways, including those activated by Wnts, hedgehog, growth factors, cytokines …
GSK-3β, a pivotal kinase in Alzheimer disease
Alzheimer disease (AD) is the most common form of age-related dementia. The etiology of
AD is considered to be multifactorial as only a negligible percentage of cases have a familial …
AD is considered to be multifactorial as only a negligible percentage of cases have a familial …
[HTML][HTML] GSK-3β in DNA repair, apoptosis, and resistance of chemotherapy, radiotherapy of cancer
J Lin, T Song, C Li, W Mao - … et Biophysica Acta (BBA)-Molecular Cell …, 2020 - Elsevier
Glycogen synthase kinase-3β (GSK-3β) is an evolutionarily conserved serine/threonine
kinase, functioning in numerous cellular processes including cell proliferation, DNA repair …
kinase, functioning in numerous cellular processes including cell proliferation, DNA repair …
Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics
Deciphering what governs inflammation and its effects on tissues is vital for understanding
many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes …
many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes …
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade
JM Beaulieu, TD Sotnikova, WD Yao… - Proceedings of the …, 2004 - National Acad Sciences
Dopamine (DA) is a neurotransmitter involved in the control of locomotion, emotion,
cognition, and reward. Administration of lithium salts is known to inhibit DA-associated …
cognition, and reward. Administration of lithium salts is known to inhibit DA-associated …
Nanoreinforced hydrogels for tissue engineering: biomaterials that are compatible with load‐bearing and electroactive tissues
Given their highly porous nature and excellent water retention, hydrogel‐based biomaterials
can mimic critical properties of the native cellular environment. However, their potential to …
can mimic critical properties of the native cellular environment. However, their potential to …
Tau phosphorylation in neuronal cell function and dysfunction
GVW Johnson, WH Stoothoff - Journal of cell science, 2004 - journals.biologists.com
Tau is a group of neuronal microtubule-associated proteins that are formed by alternative
mRNA splicing and accumulate in neurofibrillary tangles in Alzheimer's disease (AD) brain …
mRNA splicing and accumulate in neurofibrillary tangles in Alzheimer's disease (AD) brain …