Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

[HTML][HTML] Sepsis Biomarkers: Advancements and Clinical Applications—A Narrative Review

RR He, GL Yue, ML Dong, JQ Wang… - International journal of …, 2024 - mdpi.com
Sepsis is now defined as a life-threatening syndrome of organ dysfunction triggered by a
dysregulated host response to infection, posing significant challenges in critical care. The …

The glucocorticoid receptor in cardiovascular health and disease

B Liu, TN Zhang, JK Knight, JE Goodwin - Cells, 2019 - mdpi.com
The glucocorticoid receptor is a member of the nuclear receptor family that controls many
distinct gene networks, governing various aspects of development, metabolism …

Biomarkers for point-of-care diagnosis of sepsis

A Teggert, H Datta, Z Ali - Micromachines, 2020 - mdpi.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to infection. In 2017, almost 50 million cases of sepsis were recorded worldwide …

Analysis of mRNA‑lncRNA and mRNA‑lncRNA-pathway co‑expression networks based on WGCNA in develo** pediatric sepsis

X Zhang, Y Cui, X Ding, S Liu, B Han, X Duan… - …, 2021 - Taylor & Francis
Pediatric sepsis is a great threat to death worldwide. However, the pathogenesis has not
been clearly understood until now in sepsis. This study identified differentially expressed …

Circular RNAs in sepsis: biogenesis, function, and clinical significance

J Beltran-Garcia, R Osca-Verdegal, E Nacher-Sendra… - Cells, 2020 - mdpi.com
Sepsis is a life-threatening condition that occurs when the body responds to an infection that
damages it is own tissues. The major problem in sepsis is rapid, vital status deterioration in …

Long noncoding RNAs: a missing link in osteoporosis

AM Silva, SR Moura, JH Teixeira, MA Barbosa… - Bone research, 2019 - nature.com
Osteoporosis is a systemic disease that results in loss of bone density and increased
fracture risk, particularly in the vertebrae and the hip. This condition and associated …

Melatonin Alleviates Cardiac Function in Sepsis-Caused Myocarditis via Maintenance of Mitochondrial Function

L Chen, Q Tian, Z Shi, Y Qiu, Q Lu, C Liu - Frontiers in Nutrition, 2021 - frontiersin.org
Melatonin (N-acetyl-5-methoxytryptamine) has been shown to have a cardioprotective effect
against myocarditis. However, the mechanisms underlying the protective role of melatonin …

MicroRNAs in inflammatory heart diseases and sepsis-induced cardiac dysfunction: a potential scope for the future?

M Mirna, V Paar, R Rezar, A Topf, M Eber, UC Hoppe… - Cells, 2019 - mdpi.com
Background: MicroRNAs (miRNAs) are small, single-stranded RNA sequences that regulate
gene expression on a post-transcriptional level. In the last few decades, various trials have …

MicroRNAs: Key modulators of inflammation-associated diseases

B Chatterjee, M Sarkar, S Bose, MT Alam… - Seminars in Cell & …, 2024 - Elsevier
Inflammation is a multifaceted biological and pathophysiological response to injuries,
infections, toxins, and inflammatory mechanisms that plays a central role in the progression …