Abstract The Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census
(CGC) is an expert-curated description of the genes driving human cancer that is used as a …

The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages
of RNA metabolism and participates in the progression of many diseases, including virus …

Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …

Specific cell states in metazoans are established by the symphony of gene expression
programs that necessitate intricate synergic interactions between transcription factors and …

Circular RNAs (circRNA), a subclass of noncoding RNA characterized by covalently closed
continuous loops, play emerging roles in tumorigenesis and aggressiveness. However, the …

Viruses are detected by different classes of pattern recognition receptors (PRRs), such as
Toll‐like receptors and RIG‐like helicases. Engagement of PRRs leads to activation of …

Aim Blood–brain barrier (BBB) disorder is one of the early findings in cognitive impairments.
We have recently found that Porphyromonas gingivalis bacteraemia can cause cognitive …

TANK‐binding kinase 1 (TBK1) is of central importance for the induction of type‐I interferon
(IFN) in response to pathogens. We identified the DEAD‐box helicase DDX3X as an …

Abstract DDX3X is a DEAD-box RNA helicase that has been implicated in multiple aspects
of RNA metabolism including translation initiation and the assembly of stress granules …

Members of the DEAD box family of RNA helicases are known to be involved in most cellular
processes that require manipulation of RNA structure and, in many cases, exhibit other …