Cellular and molecular mechanisms regulating neuronal growth by brain‐derived neurotrophic factor

A Gonzalez, G Moya‐Alvarado… - …, 2016 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic
and axonal growth during development and maintenance of the mature nervous system; …

The exocyst complex in health and disease

M Martin-Urdiroz, MJ Deeks, CG Horton… - Frontiers in cell and …, 2016 - frontiersin.org
Exocytosis involves the fusion of intracellular secretory vesicles with the plasma membrane,
thereby delivering integral membrane proteins to the cell surface and releasing material into …

The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction

E Pajarillo, S Kim, A Digman, M Dutton, DS Son… - Journal of Biological …, 2023 - jbc.org
Chronic manganese (Mn) exposure can lead to manganism, a neurological disorder sharing
common symptoms with Parkinson's disease (PD). Studies have shown that Mn can …

Rab10-mediated secretion synergizes with tissue movement to build a polarized basement membrane architecture for organ morphogenesis

AJ Isabella, S Horne-Badovinac - Developmental cell, 2016 - cell.com
Basement membranes (BMs) are planar protein networks that support epithelial function.
Regulated changes to BM architecture can also contribute to tissue morphogenesis, but how …

Cell invasion in vivo via rapid exocytosis of a transient lysosome-derived membrane domain

KM Naegeli, E Hastie, A Garde, Z Wang, DP Keeley… - Developmental cell, 2017 - cell.com
Invasive cells use small invadopodia to breach basement membrane (BM), a dense matrix
that encases tissues. Following the breach, a large protrusion forms to clear a path for tissue …

[HTML][HTML] Deterministic and stochastic rules of branching govern dendrite morphogenesis of sensory neurons

A Palavalli, N Tizón-Escamilla, JF Rupprecht, T Lecuit - Current Biology, 2021 - cell.com
Dendrite morphology is necessary for the correct integration of inputs that neurons receive.
The branching mechanisms allowing neurons to acquire their type-specific morphology …

The functions of Reelin in membrane trafficking and cytoskeletal dynamics: implications for neuronal migration, polarization and differentiation

J Santana, MP Marzolo - Biochemical Journal, 2017 - portlandpress.com
Reelin is a large extracellular matrix protein with relevant roles in mammalian central
nervous system including neurogenesis, neuronal polarization and migration during …